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ProteomicsPPARs and c-Myc regulate metabolism of renal tubules
Different segments of renal tubules have distinct metabolic features and functions, and defective metabolism in renal tubules is involved in the pathobiology of kidney diseases. However, the mechanisms underlying the metabolic regulation in renal tubules remain to be defined. We demonstrated that th...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-15 | PXD007828 | Pride
Pparγ  ppar  c-myc  nrf2  lipid metabolism  glycolysis  renal proximal tubules  renal distal tubules  kidney 
TranscriptomicsIdentification of renal distal convoluted tubules enriched genes
The renal distal convoluted tubule DCT is a short part of the distal nephron with specific functions transporting ions and thereby modifying Na, Ca, Mg, K balance A transcriptomic analysis of the DCT was performed to identify specific gene expression which would implicate those genes in specific DCT...
ORGANISM(S): Mus musculus 
2013-11-19 | E-GEOD-51935 | biostudies-arrayexpress
TranscriptomicsJeB001: Elucidation of the distal convoluted tubule transcriptome identified new candidate players in magnesium balance
The distal convoluted tubule (DCT) plays a key role in the fine-tuning of renal Mg2+ reabsorption. In recent years, hereditary magnesium (Mg2+) transport disorders have helped to identify important players in DCT Mg2+ homeostasis. Here, we report the Mg2+-sensitive transcriptional expression of the ...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-40208 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of microdissected rat renal tubule segments
We sequenced mRNAs from glomeruli and 14 different rat renal tubule segments collected by hand microdissection. Collagenase-digested rat renal tubule segments were collected by hand microdissection. Poly(A)-mRNAs were captured from cell lysate and sequenced using paired-end protocol.
ORGANISM(S): Rattus norvegicus 
2015-03-31 | E-GEOD-56743 | biostudies-arrayexpress
TranscriptomicsHIF orchestrated metabolic shift confers protection against Acute Kidney Injury (AKI)
Renal hypoxia is widespread in acute kidney injury (AKI) of various aetiologies. Hypoxia adaptation, conferred through the hypoxia-inducible factor (HIF), appears to be insufficient. Here we show that HIF activation in renal tubules through Pax8-rtTA-based inducible knockout of von Hippel-Lindau pro...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-44925 | biostudies-arrayexpress
UnknownDistal renal tubules are deficient in aggresome formation and autophagy upon aldosterone administration.
Not available
S-EPMC4085037 | biostudies-literature
TranscriptomicsTranscription profiling by array of human chromophobe renal cell carcinoma and oncocytoma
This study aims to compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes. Experiment Overall Design: Nine cases each of chromophobe RCC and oncocytoma were analyzed by oligonucleotide microarray. Candid...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12090 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse nephron to assess circadian rhythms
Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechani...
ORGANISM(S): Mus musculus 
2009-10-30 | E-GEOD-17739 | biostudies-arrayexpress
TranscriptomicsIdentification of renal distal convoluted tubules enriched genes
The renal distal convoluted tubule DCT is a short part of the distal nephron with specific functions transporting ions and thereby modifying Na, Ca, Mg, K balance A transcriptomic analysis of the DCT was performed to identify specific gene expression which would implicate those genes in specific DCT...
ORGANISM(S): Mus musculus 
2013-11-19 | GSE51935 | GEO
GenomicsMus musculus
Identification of renal distal convoluted tubules enriched genes
PRJNA225858 | ENA
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