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ProteomicsTFIP11 competes with the Bloom syndrome helicase for binding to stalled replication forks to preserve genome stability
Replication fork reversal is a key protective mechanism against replication stress in higher eukaryotic cells and occurs via a series of coordinated enzymatic reactions. The Bloom syndrome gene product, BLM, is a member of the highly conserved RecQ helicase family and has been implicated in this pro...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042222 | Pride
Bloom syndrome helicase  replication stress  replication fork reversal  genome instability  tfip11 
TranscriptomicsInvolvement of a chromatin remodeling complex in damage tolerance during DNA replication
ATP-dependent chromatin remodeling complexes have been shown to participate in DNA replication in addition to transcription and DNA repair. However, the mechanisms of their involvement in DNA replication remain unclear. Here, we reveal a specific function of the yeast INO80 chromatin remodeling comp...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-20 | E-GEOD-18570 | biostudies-arrayexpress
UnknownReplication fork uncoupling causes nascent strand degradation and fork reversal.
Not available
S-EPMC9868089 | biostudies-literature
UnknownReplication fork reversal triggers fork degradation in BRCA2-defective cells.
Not available
S-EPMC5643541 | biostudies-literature
ProteomicsCohesin loop extrusion tethers DNA replication forks to drive their slowing and reversal
DNA replication forks challenged by genotoxic agents have a high degree of plasticity to ensure their stability, allowing replicative tolerance and complete genome duplication. How genome architectural factors influence this response is less understood. We have investigated the role of cohesin and i...
ORGANISM(S): Homo sapiens (Human) 
2026-08-05 | PXD071150 | Pride
Ipond Replication fork Cohesin 
UnknownFork Reversal Safeguards Epigenetic Inheritance During Replication Stress.
Not available
S-EPMC12869582 | biostudies-literature
UnknownCells defective for replication restart undergo replication fork reversal.
Not available
S-EPMC1299077 | biostudies-literature
UnknownDisparate requirements for RAD54L in replication fork reversal.
Not available
S-EPMC11551752 | biostudies-literature
UnknownRADX prevents genome instability by confining replication fork reversal to stalled forks.
Not available
S-EPMC8286330 | biostudies-literature
TranscriptomicsMre11 suppresses replication stress and gene amplification proficiency
Gene amplification, copy-number increases of particular genes and surrounding genomic segments, promotes cancer progression and acquired therapy resistance. Thus, understanding genetic traits that confer gene amplification proficiency is important. The primary step for gene amplification is sponta...
ORGANISM(S): Cricetulus griseus 
2015-03-05 | E-GEOD-59487 | biostudies-arrayexpress
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