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TranscriptomicsThe regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure.
Following parenchymal loss, the liver regenerates restoring normal mass and metabolic function. Prevailing theories on triggering events leading to regeneration include humoral, metabolic and flow-mediated mechanisms, the latter emphasizing the importance of shear stress mediated nitric oxide (NO) r...
ORGANISM(S): Sus scrofa 
2008-01-14 | E-GEOD-6860 | biostudies-arrayexpress
TranscriptomicsMicroRNA array analysis during the regenerative peak following rat liver resection
The liver has the unique capacity to regenerate after surgical resection. However, the regulation of liver regeneration is not completely understood. We performed miRNA microarray analyses of liver tissue from Wistar rats at different time points after 70% partial hepatectomy (0, 2, 6, 12, 24, 48 ho...
ORGANISM(S): Rattus norvegicus 
2011-03-28 | E-GEOD-23696 | biostudies-arrayexpress
TranscriptomicsMicroRNA Profile Predicts Recurrence of Hepatocellular Carcinoma in Milan Criteria Cases with Mild Liver Cirrhosis.
In this study, we utilized microRNA expression profiling to assess risk of HCC recurrence after liver resection. We examined microRNA expression profiling in paired tumor and non-tumor liver tissues of 73 HCC patients with mild cirrhosis (Child-Pugh A/B) who satisfy Milan Criteria. We constructed pr...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-21362 | biostudies-arrayexpress
TranscriptomicsThe Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends
Chromosomal double-strand breaks (DSBs) are resected by 5M-bM-^@M-^Y-nucleases to form 3M-bM-^@M-^Y single-strand DNA (ssDNA) substrates for binding by homologous recombination and DNA damage checkpoint proteins. Two redundant pathways of extensive resection were described both in cells and in vitro...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-04 | E-GEOD-38601 | biostudies-arrayexpress
ProteomicsDepletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to maintain genome stability. DSB resection generates a single strand DNA intermediate, which is crucial for the HR process. We used a synthetic DNA structure, mimicking a resection intermediate, as a bait to ident...
ORGANISM(S): Homo sapiens (Human) 
2019-02-26 | PXD012045 | Pride
Rna binding proteins  hnrnpd  dna damage  dna end resection  rna binding proteins  r-loop 
TranscriptomicsTranscriptomic characterization of the impact of 2'-fucosyllactose supplementation on intestinal adaptation following ileocecal resection.
Purpose: To identify the impact of 2'-FL supplementation on adaptive response following extensive intestinal resection. Methods: Transcriptomic profiles were obtained from mice undergoing ileocecal recection (8-10 week old male mice) and again at 8 weeks post-surgery. At the time of resection and...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-72590 | biostudies-arrayexpress
GenomicsRif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its ph...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42298 | biostudies-arrayexpress
GenomicsRole of CRY1 in DNA end resection
Role of CRY1 in DNA end resection
PRJNA1086926 | ENA
ProteomicsLiquid chromatography mass spectrometry-based nontargeted metabolomics predicts prognosis of hepatocellular carcinoma after curative resection
Assessment and prediction of prognostic risk in patients with hepatocellular carcinoma (HCC) would greatly benefit the optimal treatment selection. Here, we aimed to identify the critical metabolites associated with the outcomes and develop a risk score to assess the prognosis of HCC patients after ...
ORGANISM(S): Homo Sapiens 
PXD019864 |
ProteomicsPhosphoproteomic Datasets for Mec1/ATR Signaling Upon Hyper-Resection (TMT Supplement)
The Mec1/ATR kinase is crucial for genome maintenance, although the mechanisms by which it controls DNA repair pathways remain elusive. Here we uncovered a role for Mec1/ATR in controlling homologous recombination (HR) factors in response to hyper-resection of DNA ends. Cells lacking RAD9, a checkpo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-10 | PXD023438 | Pride
Mec1 Sgs1 Silac Phosphoproteomics Resection 
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