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MetabolomicsTargeted metabolomic profiling of myocardial remodeling after STEMI

Early detection of myocardial remodeling is essential for optimizing outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, reliable biomarkers for predicting STEMI myocardial remodeling remain scarce.

Targeted metabolomic profiling was performed on plasma ...

2025-09-02 | MTBLS10634 | MetaboLights
MetabolomicsBanana flower polysaccharides promote immunoprotection through gut microbiota-associated host metabolic remodeling

The gut microbiota is increasingly recognized as an important mediator of the systemic effects of dietary polysaccharides, but how microbiota remodeling is associated with host metabolic responses remains poorly understood. Here, we investigated hepatic metabolic remodeling associated with the im...

2026-09-01 | MTBLS15462 | MetaboLights
MetabolomicsIntraoperative intestinal ischemia-reperfusion injury aggravates postoperative delirium by remodeling gut microbiota
Postoperative delirium, is a notable and serious complication after surgery, commonly extending hospitalization by 2-3 days. In a cohort of 167 patients, elevated serum intestinal fatty acid binding protein (I-FABP) was identified as an independent risk factor for postoperative delirium. Complementa...
2026-03-30 | MTBLS14186 | MetaboLights
MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
MetabolomicsArsenic induces metabolome remodeling in mature human adipocytes
Human lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the deve...
2025-05-23 | MTBLS8808 | MetaboLights
ProteomicsPericardial fluid proteome profile in aortic stenosis patients with complete or incomplete reverse remodeling
Patients with aortic stenosis are often indicated to aortic valve replacement to relief pressure overload. After surgery, patients experience a myocardial response commonly known as reverse remodeling, where structural and functional recovery are expected. Notwithstanding, some patients exhibit an i...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD015607 | Pride
Human Coronary artery disease Aortic stenosis Pericardial fluid Reverse remodeling 
MetabolomicsHistone serotonylation promotes pancreatic cancer development via lipid metabolism remodeling

Neurotransmitter serotonin (5-hydroxytryptamine [5-HT]) has emerged to play parallel roles in both neurobiology and oncology. Apart from receptor-mediated signaling transduction pattern, serotonin can be covalently integrated into histone (the post-translational modification known as histone sero...

2025-06-13 | MTBLS12569 | MetaboLights
MetabolomicsOxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina

The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and patho...

2023-05-09 | MTBLS6965 | MetaboLights
MetabolomicsHuman Cytomegalovirus pUL37x1 is Important to Remodeling of Host Lipid Metabolism
Human cytomegalovirus (HCMV) replication requires host metabolism. Infection alters the activity in multiple metabolic pathways, including increasing fatty acid elongation and lipid synthesis. The virus-host interactions regulating the metabolic changes associated with replication are essential to i...
2020-06-26 | MTBLS1073 | MetaboLights
MetabolomicsFunctional Remodeling of the Gut Microbiome and Metabolome in Primary Idiopathic Male Infertility

Abstract

Background: Primary idiopathic male infertility (PIMI) is a complex condition with unclear biological mechanisms. Increasing evidence indicates that gut microbiome-derived functional and metabolic alterations can influence host physiological processes, yet microbiome-associated fun...

2026-04-07 | MTBLS13886 | MetaboLights
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