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TranscriptomicsColorectal tissue gene expression in SIV negative and SIV positive Rhesus macaques and sooty mangabeys
In SIV/HIV infection, the gastrointestinal tissue dominates as an important site due to the impact of massive mucosal CD4 depletion and immune activation-induced tissue pathology. Unlike AIDS-susceptible rhesus macaques, natural hosts do not progress to AIDS and resolve immune activation earlier. He...
ORGANISM(S): Macaca mulatta 
2011-09-05 | E-GEOD-29980 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of two macaques, crab-eating macaque and Indian rhesus macaque
Deep sequencing of mRNA from two macaques, crab-eating macaque and Indian rhesus macaque Analysis of ploy(A)+ RNA of different specimens:brain,ileum,kidney,liver,testes and white adipose for crab-eating macaque while brain,heart,,kidney,liver,quadriceps and testes for Indian rhesus macaque
ORGANISM(S): Macaca mulatta 
2011-10-13 | E-GEOD-29629 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of experimental CD8+ lymphocyte depletion in rhesus macaques infected with SIVmac239
CD8+ T-cells inhibit virus replication in SIV-infected rhesus macaques (RM). However, it is unclear to what extent the viral suppression mediated by CD8+ T-cells reflects direct killing of infected cells as opposed to indirect, non-cytolytic mechanisms. In this study, we used functional genomics to ...
ORGANISM(S): Macaca mulatta 
2013-02-08 | E-GEOD-37834 | biostudies-arrayexpress
TranscriptomicsGene expression in the blood of SIV infected Rhesus macaques following in vivo PD-1 blockade
Hyperimmune activation is one of the strong predictors of disease progression during pathogenic immunodeficiency virus infections and is mediated in part by sustained type I interferon (IFN) signaling. Combination antiretroviral therapy suppresses hyperimmune activation only partially in HIV-infecte...
ORGANISM(S): Macaca mulatta 
2012-04-26 | E-GEOD-33933 | biostudies-arrayexpress
GenomicsDramatic effects of social behavior on gene regulation in rhesus macaques [Bisulfite seq]
These data are a component of a larger study investigating differences in gene regulation in relationship to rhesus macaque dominance rank. These data compare DNA methylation levels between individuals of different rank on a genome-wide scale using bisulfite sequencing DNA from peripheral blood mono...
ORGANISM(S): Macaca mulatta 
2012-02-01 | E-GEOD-34128 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of lentivirally-transduced rhesus macaque CD34+ cells long-term following transplant
The occurrence of clonal perturbations and leukemia in patients transplanted with retrovirally-transduced autologous hematopoietic stem and progenitor cells (HSPCs) has stimulated extensive investigation, demonstrating that proviral insertions perturb adjacent proto-oncogene expression. Although enh...
ORGANISM(S): Macaca mulatta 
2013-11-05 | E-GEOD-46032 | biostudies-arrayexpress
ProteomicsWhole milk proteome of human and rhesus macaque during peak lactation
Milk has been well established as the optimal nutrition source for infants, yet there is still much to be understood about its molecular composition. Therefore, our objective was to develop and compare comprehensive milk proteomes for human and rhesus macaques to highlight differences in neonatal nu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Macaca Mulatta (ncbitaxon:9544) 
2015-02-23 | MSV000079045 | MassIVE
TranscriptomicsEffect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques (TEM)
Analysis of the effect of anti-IL-15 monoclonal antibody treatment on T cell and NK cell homeostasis in rhesus macaques. The hypothesis tested in the present study was that repeated administrations of a rhesusized anti-IL-15 monoclonal antibody would block IL-15 activity in vivo and result in change...
ORGANISM(S): Macaca mulatta 
2016-09-07 | E-GEOD-76796 | biostudies-arrayexpress
TranscriptomicsGeneration of Naïve Induced Pluripotent Stem Cells from Rhesus Monkey Fibroblasts
Conventional embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) derived from primates resemble mouse epiblast stem cells, raising an intriguing question regarding whether the naïve pluripotent state resembling mouse embryonic stem cells (mESCs) exists in primates and how to captur...
ORGANISM(S): Macaca mulatta 
2014-10-14 | E-GEOD-61420 | biostudies-arrayexpress
TranscriptomicsExpression data from 5 rhesus tissues at 3 centers
Novel approaches were used to generate the DNA sequence information for the rhesus GeneChip (2005). The purpose of this experiment was to test its reliability and validity of the rhesus macaque GeneChip across different tissues and centers. Keywords: reliability To test the reliability of the rhesus...
ORGANISM(S): Macaca mulatta 
2010-06-11 | E-GEOD-7094 | biostudies-arrayexpress
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