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ProteomicsRhoJ controls EMT associated resistance to chemotherapy
The resistance of cancer cell to therapy is responsible of the death of most cancer patients. Epithelial to mesenchymal transitions (EMT) has been associated with resistance to therapy in different cancer cells. However, the mechanisms by which EMT mediates resistance to therapy remain poorly unders...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-13 | PXD025737 | Pride
Cancer  emt  therapy resistance  rhoj 
ProteomicsRhoJ controls EMT associated resistance to chemotherapy
The resistance of cancer cells to therapy is responsible for the death of most cancer patients. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to therapy in different cancer cells. However, the mechanisms by which EMT mediates resistance to therapy remain poorly under...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-13 | PXD038278 | Pride
Cancer Mus musculus (mouse) Cell culture Scc Ap-lc-ms/ms 
GenomicsRhoJ controls EMT associated resistance to chemotherapy
RhoJ controls EMT associated resistance to chemotherapy
PRJNA848761 | ENA
TranscriptomicsRhoJ controls EMT associated resistance to chemotherapy
To identify potential mechanisms by which EMT tumour cells are resistant to chemotherapy, we assessed the expression of putative mediators of resistance to therapy in Epcam+ and Epcam- tumour cells from skin squamous cell carcinoma. To determine how RhoJ impacts the transcriptional landscape of Epca...
ORGANISM(S): Mus musculus 
2023-01-13 | GSE205985 | GEO
TranscriptomicsThe RhoJ-BAD Signaling Network: An Achilles Heel for BRAF Mutant Melanomas
Genes and pathways that allow cells to cope with oncogene-induced stress represent selective cancer therapeutic targets that remain largely undiscovered. In this study, we identify a RhoJ signaling pathway that is a selective therapeutic target for BRAF mutant cells. RhoJ deletion in BRAF mutant mel...
ORGANISM(S): Mus musculus 
2017-07-26 | GSE101859 | GEO
UnknownOncogenic Gαq activates RhoJ through PDZ-RhoGEF.
Not available
S-EPMC10647656 | biostudies-literature
UnknownRHOJ controls EMT-associated resistance to chemotherapy.
Not available
S-EPMC10076223 | biostudies-literature
UnknownRhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics.
Not available
S-EPMC4528913 | biostudies-literature
UnknownRhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.
Not available
S-EPMC4106786 | biostudies-literature
UnknownRhoJ integrates attractive and repulsive cues in directional migration of endothelial cells.
Not available
S-EPMC7298304 | biostudies-literature
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