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GenomicsChIP-seq in the cell line NALM-6 for RUNX1 and ETV6-RUNX1 to assess competition between the two proteins for DNA binding
RUNX1 and ETV6-RUNX1 possess the same DNA-binding runt domain and are therefore expected to bind to canonical RUNX motifs. As the ETV6-RUNX1 fusion arises in the context of native RUNX1 expression, and since RUNX1 is retained or amplified in B-ALL, the two proteins are likely to compete for the same...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12209 | biostudies-arrayexpress
TranscriptomicsDynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line models
This SuperSeries is composed of the following subset Series: GSE24777: Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners GSE24778: Expresssion data in K562 cells, before and after TPA induction and including ...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24779 | biostudies-arrayexpress
GenomicsRegulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners
Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners Examination of RUNX1 binding in K562 cells, before and following TPA induction and CMK cells. Examination of GATA1 and FOS binding and H3K4me1 and H3K27me3 mo...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24777 | biostudies-arrayexpress
GenomicsHistone H3, lysine 27 acetylation ChIP-seq in NALM6 expressing ETV6-RUNX1
ETV6-RUNX1 is a fusion protein bringing together almost the entire coding sequence of RUNX1, including the DNA binding runt domain, and the N-terminus of ETV6 which is known to include transcriptional repressors including histone deacetylation 3 (HDAC3). Here we perform ChIP-seq for the active chrom...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12207 | biostudies-arrayexpress
TranscriptomicsRUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.
RUNX1 is a transcription factor functioning both as an oncogene and a tumor suppressor in breast cancer. RUNX1 alters chromatin structure in cooperation with chromatin modifier and remodeling enzymes. In this study, we examined the relationship between RUNX1-mediated transcription and genome organiz...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-75070 | biostudies-arrayexpress
ProteomicsIdentification of RUNX1 binding proteins in control and entinostate treated mouse leukemia cells
Runt-related Transcription Factor 1 (RUNX1) is essential for definitive hematopoiesis and is among the most frequently mutated genes in leukemia. Previous work from our lab demonstrated that Histone Deacetylase 1 (HDAC1), a known RUNX1 partner, is unexpectedly required for active transcription sugge...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-19 | PXD068027 | Pride
Hdac1 Leukemia Ptbp1 Runx1 Aml 
ProteomicsA T-cell receptor targeting RUNX1 frameshift mutations in acute myeloid leukemia
Runt-related transcription factor 1 (RUNX1) is a key regulator of hematopoietic differentiation. Disruption of RUNX1 in acute myeloid leukemia (AML) induces a maturation arrest and early myeloid progenitor phenotype. RUNX1 mutations occur in 10-15% of AML and are associated with poor prognosis. One-...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD062938 | Pride
Tcr-based immunotherapy Hla-peptidomics Runx1 Aml 
GenomicsGenome-wide mapping of Runx1-bound sites in early B-cell progenitors
The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investig...
ORGANISM(S): Mus musculus 
2013-05-27 | E-GEOD-45377 | biostudies-arrayexpress
TranscriptomicsExpresssion data in K562 cells, before and after TPA induction and including a RUNX1 knockout construct or a control structure
Expresssion data in K562 cells, before and after TPA induction and including a RUNX1 knockout construct or a control structure Examination of gene expression in K562 cells, before and following TPA induction and with or without a RUNX1 KO construct or control
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24778 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal progenitor cells mutated for RUNX1-RUNX1 during myeloid and erythroid development to identify genes disregulated by RUNX1-RUNX1
In order to identify genes dysregulated by the aberrant transcriptional activity of RUNX1-RUNX1T1, we used microarrays to determine the effect of this mutation on gene expression during myeloid and erythroid development of normal human progenitor cells.
ORGANISM(S): Homo sapiens 
2007-10-01 | E-MEXP-583 | biostudies-arrayexpress
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