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TranscriptomicsHDAC1/2 and CD4+ T cells
Dynamic changes in histone acetylation patterns are mediated by the activity of histone acetyltransfereases (HATs) and histone deacetylases (HDACs) and are key events in the epigenetic regulation of gene expression. The application of HDAC inhibitors revealed a variety of T cell functions controlled...
ORGANISM(S): Mus musculus 
2014-03-30 | E-MTAB-2184 | biostudies-arrayexpress
TranscriptomicsZebrafish 27hpf embryos: hdac1 mutant (hi1618) vs sibling
Transcriptional profiling of hdac1 mutant zebrafish in comparison to their sibling embryos. Embryos resulting from a cross between heterozygous hdac1 mutant zebrafish (hi1618/+) where cultured together then mutants separated from the siblings one the basis of phenotype and RNA extracted from the tw...
ORGANISM(S): Danio rerio 
2011-01-21 | E-GEOD-26707 | biostudies-arrayexpress
TranscriptomicsZebrafish hdac1 mutant and morphant embryos
This SuperSeries is composed of the following subset Series: GSE26707: Zebrafish 27hpf embryos: hdac1 mutant (hi1618) vs sibling GSE26708: Zebrafish embryos: hdac1 Morphants vs Standard control morphants GSE26709: Zebrafish embryos: hdac1 Morphants vs Standard control morphants at 12, 18 and 27 hpf ...
ORGANISM(S): Danio rerio 
2011-01-21 | E-GEOD-26710 | biostudies-arrayexpress
TranscriptomicsFunctional Roles of Hdac1/2 in lung development
Hdac1/2 are important epigenetic factors, yet their functional roles in specific tissues inluding lung is not determined. We used the conditional knockout model of Hdac1/2 to determine their roles in lung development. To explore the genes that are regulated by Hdac1/2 during lung development, we per...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39946 | biostudies-arrayexpress
TranscriptomicsFunctions of HDAC1 and HDAC2 in Schwann cells during postnatal
The aim of our study is to determine the functions of histone deacetylases (HDACs) 1 and 2 in Schwann cells during postnatal development of the peripheral nervous system (PNS). Schwann cells are the myelinating glial cells of the PNS. At birth, mouse sciatic nerves mature in 2 subsequent phases: 1/ ...
ORGANISM(S): Mus musculus 
2011-02-25 | E-GEOD-27451 | biostudies-arrayexpress
TranscriptomicsPrimary human erythroid progenitor cells HDAC1 and HDAC2 shRNA knockdown samples
Gene expression profiling was performed on primary human erythroid progenitor cells expressing a control shRNA (luciferase), two different HDAC1 shRNAs, and two different HDAC2 shRNAs. The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year ...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22366 | biostudies-arrayexpress
TranscriptomicsZebrafish embryos: hdac1 Morphants vs Standard control morphants
Transcriptional profiling of hdac1 morphant zebrafish embryos in comparison to standard control injected embryos. Embryos where injected at the one cell stage with either a translation blocking morpholino (Hdac1 ATG), splice blocking morpholino (Hdac1 Splice) or Hdac1 mismatch control morpholino (H...
ORGANISM(S): Danio rerio 
2011-01-21 | E-GEOD-26708 | biostudies-arrayexpress
TranscriptomicsThe acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis
Histone deacetylases (Hdac) remove acetyl groups from proteins, influencing global and specific gene expression. Hdacs control inflammation, as shown by Hdac inhibitor-dependent protection from DSS-induced murine colitis. While tissue-specific Hdac knockouts show redundant and specific functions, li...
ORGANISM(S): Mus musculus 
2014-02-08 | E-GEOD-54785 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of embryonic stem cells from wild type and histone deacetylase 1 (HDAC1) knock out mice to identify putative HDAC1 target genes.
Histone deacetylase 1 (HDAC1) is an enzyme that promotes deacetylation of acetylated lysine residues in histones and other proteins. Histone acetylation is often associated with gene activation and expression. Los of HDAC1 leads to severe problems in development and proliferation. Moreover, it seems...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5583 | biostudies-arrayexpress
TranscriptomicsZebrafish embryos: hdac1 Morphants vs Standard control morphants at 12, 18 and 27 hpf
Transcriptional profiling of hdac1 ATG morphant zebrafish embryos in comparison to standard control injected embryos. Embryos where injected at the one cell stage with either a translation blocking morpholino (Hdac1 ATG) or Standard control morpholino (StCo). RNA was extracted at 12, 18 and 27hpf ...
ORGANISM(S): Danio rerio 
2011-01-21 | E-GEOD-26709 | biostudies-arrayexpress
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