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ProteomicsHeart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2.
Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and quality of life. Although, ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle dysfunction, its role in CD remains unclear. Here, we show in hippocampal neurons from patients and mice with HF t...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-30 | PXD042295 | Pride
Calcium Cognitive dysfunction Heart failure Ryanodine receptor 
TranscriptomicsDNA methylation profiles (RRBS) of the muscle of pigs distinct in metabolic types and genetic background
DNA methylation is an epigenetic mechanism that plays roles in gene regulation and expression. This study aims to profile DNA methylation at genome-wide scale and single base resolution using reduced representation bisulfite sequencing (RRBS) of the muscle of pigs differing in muscle metabolism and ...
ORGANISM(S): Sus scrofa 
2024-12-01 | E-MTAB-7338 | biostudies-arrayexpress
ProteomicsPhosphorylation-dependent Interactome of Ryanodine Recep-tor Type-2 in the Heart
Background: Hyperphosphorylation of the calcium release channel/ryanodine receptor type 2 (RyR2) at serine 2814 (S2814) is associated with multiple cardiac diseases including atrial fibrilla-tion and heart failure. Despite recent advances, the molecular mechanisms driving pathological changes associ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-07 | PXD026350 | Pride
Ryr2 Heart Phosphorylation Interactome 
GenomicsFoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells
FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells
PRJNA993577 | ENA
UnknownStructural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Not available
S-EPMC11402997 | biostudies-literature
TranscriptomicsExpression in myocardial tissues of Great Dane dogs with cardiomyopathy
Oligonucleotide microarray analysis of left ventricular tissues from 3 Great dane dogs with dilated cardiomyopathy and 3 control dogs was performed. Three hundred and twenty three differentially expressed transcripts were detected. The transcript demonstrating the highest degree of upregulation wa...
ORGANISM(S): Canis lupus familiaris 
2010-04-09 | E-GEOD-16049 | biostudies-arrayexpress
UnknownInsights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2).
Not available
S-EPMC4216943 | biostudies-literature
ProteomicsJunctophilin 2 (JPH2) and ryanodine receptor 2 (RYR2) protein complex in WT and FKBP12 deficient mice heart
To determine if the absence of FKBP12 in cardiac tissue alters JPH2 and RYR2 interactions with other dyadic proteins, we immunoprecipitated JPH2 from hearts of FL, MCK-FKD, MHC-Cre+ only, and MHC-FKD mice.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-12-04 | MSV000096593 | MassIVE
UnknownQuantitative Single-Molecule Analysis of Ryanodine Receptor 2 Subunit Assembly in Cardiac and Neuronal Tissues.
Not available
S-EPMC12277025 | biostudies-literature
GenomicsFoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells
The suppression mechanism of regulatory T cells (Tregs) is an intensely investigated topic. As our focus has shifted towards a model centered on indirect inhibition of dendritic cells, a universally applicable effector mechanism controlled by the transcription factor forkhead box P3 (FoxP3) expressi...
ORGANISM(S): Mus musculus 
2023-12-20 | GSE237032 | GEO
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