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UnknownComparison of Capillary and Schirmer Strip Tear Fluid Sampling Methods Using SWATH-MS Proteomics Approach.
Not available
S-EPMC7351636 | biostudies-literature
ProteomicsProteomic Analysis of Human Conjunctival Cells and Tears Collected with Schirmer Strips Using TimsTOF Pro
This study aimed to investigate the human tear proteins extracted from whole (W) Schirmer strips (ScS) and their two parts, the bulb (B) and the rest of the strip (R) with a comprehensive proteomic approach using a trapped ion mobility mass spectrometer, the timsTOF Pro. Eight ScS were collected fro...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD030334 | Pride
Proteomics Conjunctival cells Schirmer strips Tears Timstof pro 
ProteomicsMass spectrometric detection of keratins in tear fluid
Keratin contamination is a common problem in mass spectrometry proteomic analyses, particularly in bottom-up mass spectrometry. The purpose of this study was to determine the protein contaminants introduced during the proteomic analysis of tear fluid.Human tear fluid samples were collected using Sch...
ORGANISM(S): Homo sapiens (Human) 
2025-03-03 | PXD061409 | Pride
Tear fluid Keratins Schirmer strip Mass spectrometry Proteomics Biomarkers 
ProteomicsTear proteomics of young patients wearing glasses, orthokeratology lenses, and soft contact lenses
Contact lens-related ocular surface complications occur more often in teenagers and young adults. The purpose of this study was to determine changes in tear proteome of young patients wearing glasses (GL), orthokeratology lenses (OK), and soft contact lenses (SCL). Twenty-two young patients (10-26 y...
ORGANISM(S): Homo sapiens (Human) 
2022-11-07 | PXD029188 | Pride
Human Soft contact lens Schirmer strip Orthokeratology Tears 
ProteomicsTear Fluid Proteomics: A Comparative Study of DIA and DDA Mass Spectrometry
Background: Mass spectrometry is a powerful technique for tear fluid proteomics, offering critical insights into its complex molecular composition. Data-dependent acquisition (DDA), the most commonly used approach, preferentially selects high-abundance proteins, limiting reproducibility and the quan...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-10-20 | PXD062423 | Pride
Tear fluid  schirmer strip  proteomics  biomarkers  mass spectrometry 
ProteomicsTear Fluid Proteomics: A Comparative Study of DIA and DDA Mass Spectrometry
Background: Mass spectrometry is a powerful technique for tear fluid proteomics, offering critical insights into its complex molecular composition. Data-dependent acquisition (DDA), the most commonly used approach, preferentially selects high-abundance proteins, limiting reproducibility and the quan...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-10-20 | PXD062422 | Pride
Tear fluid  schirmer strip  proteomics  biomarkers  mass spectrometry 
UnknownTear Strip Meniscometry and Its Clinical Application: Analysis of More Than 2000 Cases.
Not available
S-EPMC9078076 | biostudies-literature
MetabolomicsTear lipidomics profiling reveals ocular-surface lipid remodeling associated with organelle stress in a mouse model of inflammatory dry eye disease
This study aimed to determine whether dry eye disease (DED) is accompanied by ocular-surface lipid remodeling and whether such changes converge on organelle stress–associated pathways in a mouse model of inflammatory dry eye. Tear samples were collected from mice and analyzed by LC–MS/MS–based non-t...
2026-04-04 | MTBLS14217 | MetaboLights
MetabolomicsTear lipidomics profiling reveals inflammatory dry eye disease-associated lipid metabolic remodeling at the ocular surface
This study aimed to investigate whether inflammatory dry eye disease (DED) is accompanied by abnormal lipid metabolic remodeling at the ocular surface. Tear samples were collected from patients with DED and matched healthy controls. Lipidomics profiling was performed using LC–MS/MS with a standardiz...
2026-04-03 | MTBLS14218 | MetaboLights
ProteomicsInvestigation of inter- and intra-day variability of tear fluid regarding flow rate, protein concentration as well as protein composition
Purpose: Determination of inter- and intra-day variations in tear flow rate, tear fluid protein concentration as well as protein composition regarding their impact for future biomarker studies.Methods: Tear fluid was collected non-invasively from 18 healthy subjects performing Schirmer tests at four...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037811 | Pride
Mass spectrometry Tear fluid Schirmer test Tear flow rate  tear volume Protein concentration 
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