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ProteomicsSchlafen 5 as a Novel Therapeutic Target in Pancreatic Ductal Adenocarcinoma
We provide evidence that a member of the human Schlafen (SLFN) family of proteins, SLFN5, is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Targeted deletion of SLFN5 results in decreased PDAC cell proliferation and suppresses PDAC tumorigenesis in in vivo PDAC models. Importantly, ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-14 | PXD021749 | Pride
Schlafen 5 Pancreatic ductal adenocarcinoma 
UnknownRecurrent Evolutionary Innovations in Rodent and Primate Schlafen Genes.
Not available
S-EPMC12492265 | biostudies-literature
UnknownStructural and biochemical characterization of human Schlafen 5.
Not available
S-EPMC8789055 | biostudies-literature
UnknownSchlafen 3, a novel gene, regulates colonic mucosal growth during aging.
Not available
S-EPMC2670681 | biostudies-literature
GenomicsSchlafen 5 Suppresses Human Immunodeficiency Virus Type 1 Transcription by Commandeering Cellular Epigenetic Machinery
Schlafen 5 Suppresses Human Immunodeficiency Virus Type 1 Transcription by Commandeering Cellular Epigenetic Machinery
PRJNA811597 | ENA
ProteomicspiRNA processing by a trimeric Schlafen-domain-containing nuclease
Transposable elements are genomic parasites that expand within and spread between genomes. Piwi proteins control transposon activity, notably in the germline. These proteins recognize their targets through small RNA co-factors named piRNAs, making piRNA biogenesis a key specificity-determining step ...
ORGANISM(S): Caenorhabditis elegans 
2023-10-24 | PXD039502 | Pride
Interactomics  lc-ms/ms 
UnknownGeneration of Schlafen 8-Specific Antibodies.
Not available
S-EPMC12938254 | biostudies-literature
GenomicsEscherichia phage T5
Bacterial Schlafen proteins mediate phage defense [phage genome seq]
PRJNA1272589 | ENA
UnknownCan Schlafen 11 Help to Stratify Ovarian Cancer Patients Treated with DNA-Damaging Agents?
Not available
S-EPMC9139752 | biostudies-literature
UnknownpiRNA processing by a trimeric Schlafen-domain nuclease.
Not available
S-EPMC10567574 | biostudies-literature
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