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ProteomicsLable-free LC-MSMS in HeLa on DYRK3 and Sec16A, Human cervical cancer cells
In order to identify sites of the SEC16A specifically phosphorylated by the Dual Specificity Kinase DYRK3, mCherry-SEC16A was transiently over expressed in HeLa cells together with GFP-DYRK3 or EGFP-C1 only
ORGANISM(S): Homo sapiens (Human) 
2023-06-23 | PXD041620 | Pride
Hela Lable-free lc-msms Dyrk3 Sec16a 
ProteomicsFunctional Dissection of the Retrograde Shiga Toxin Trafficking Inhibitor Retro-2
The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes, and the relocalization of the Golgi SNARE protein syntaxin-5 to the endoplasmic reticulum. The molecular mechanisms by wh...
ORGANISM(S): Homo sapiens (Human) 
2020-02-24 | PXD015642 | Pride
Er exit site Sec16a Retro-2 Syntaxin5 Shiga toxin Mass spectrometry Retrograde transport 
UnknownSec16A is critical for both conventional and unconventional secretion of CFTR.
Not available
S-EPMC5220342 | biostudies-literature
UnknownPhosphorylation-coupled autoregulation of TANGO1 and Sec16A maintains functional ER exit sites.
Not available
S-EPMC12647149 | biostudies-literature
UnknownSEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.
Not available
S-EPMC4932369 | biostudies-literature
UnknownSEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress.
Not available
S-EPMC11481239 | biostudies-literature
UnknownLeucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
Not available
S-EPMC4253522 | biostudies-literature
UnknownSec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.
Not available
S-EPMC5754088 | biostudies-literature
ProteomicsDIA-based proteomic profiling of iPSC-derived neurons with SEC16A mutation
SEC16A encodes a scaffold protein that organizes the endoplasmic reticulum (ER) exit sites, specialized ER subdomains that mediate export of newly synthesized proteins and regulate early secretory pathway steps. The role of SEC16A in human nervous system diseases has not been established yet. Here, ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-30 | PXD083732 | Pride
Human Patient ipsc-derived neurons 
UnknownPrivate rare deletions in SEC16A and MAMDC4 may represent novel pathogenic variants in familial axial spondyloarthritis.
Not available
S-EPMC4819618 | biostudies-literature
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