Sort   by:  
 Page size 
MetabolomicsDIAMetAlyzer allows automated false-discovery rate-controlled analysis for data-independent acquisition in metabolomics
The extraction of meaningful biological knowledge from high-throughput mass spectrometry data relies on limiting false discoveries to a manageable amount. For targeted approaches in metabolomics a main challenge is the detection of false positive metabolic features in the low signal-to-noise ranges ...
2022-09-05 | MTBLS1108 | MetaboLights
ProteomicsSerum glycoprotein biomarker discovery and qualification pipeline reveals novel diagnostic biomarkers for esophageal adenocarcinoma
The aim of this project is to identify circulatory diagnostic glycoprotein biomarkers for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Serum samples from healthy, BE and EAC patients were screened using LeMBA-LC-MS/MS-GlycoSelector pipeline as described in the manuscript.
ORGANISM(S): Homo sapiens (Human) 
2015-09-25 | PXD002442 | Pride
Barrett's esophagus (be) Esophageal adenocarcinoma (eac) Biomarker Glycoprotein Lectin 
ProteomicsDiscovery and qualification of serum protein biomarkers for cholangiocarcinoma diagnosis
The aim of the study is to discover and qualify serum protein biomarkers for cholangiocarcinoma diagnosis. Serum samples from normal, periductal fibrosis and CCA groups were screened using LC-MS/MS and MRM/MS as described in manuscript.
ORGANISM(S): Homo sapiens (Human) 
2019-08-26 | PXD011804 | Pride
Cholangiocarcinoma  proteomics  mass spectrometry  multiple reaction monitoring  serum biomarker discovery pipeline 
ProteomicsA new panel of pancreatic cancer biomarkers discovered using a mass spectrometry-based pipeline
Pancreatic carcinoma (PC) is an aggressive malignancy that lacks strategies for early detection. This study aimed to develop a coherent, high-throughput and non-discriminatory pipeline for the novel clinical biomarker discovery of PC. On the basis of the newly developed pipeline, we identified >1000...
ORGANISM(S): Homo Sapiens 
2020-10-23 | PXD022140 |
ProteomicsProteomics of Cerebrospinal Fluid: Throughput and Robustness Using a Scalable Automated Analysis Pipeline for Biomarker Discovery
Cerebrospinal fluid (CSF) is a body fluid of high clinical relevance and an important source of potential biomarkers for brain-associated damages such as traumatic brain injury, stroke, and for brain diseases like Alzheimer’s and Parkinson's . Herein, we have implemented, evaluated and validated a ...
ORGANISM(S): Homo sapiens (Human) 
2015-12-09 | PXD003024 | Pride
Depletion Automation Tandem mass tags Brain Mass spectrometry Clinical proteomics Isobaric labeling 
UnknownSerum Glycoprotein Biomarker Discovery and Qualification Pipeline Reveals Novel Diagnostic Biomarker Candidates for Esophageal Adenocarcinoma.
Not available
S-EPMC4638044 | biostudies-literature
ProteomicsA pipeline for discovery and verification of glycoproteins from plasma-derived extracellular vesicles as breast cancer biomarkers
Glycoproteins comprise more than half of current FDA-approved protein cancer markers but the development of new glycoproteins as disease biomarkers has been stagnant. Here we present a pipeline to develop glycoproteins from extracellular vesicles (EVs) through integrating quantitative glycoproteomic...
ORGANISM(S): Homo sapiens (Human) 
2018-04-26 | PXD007572 | Pride
Extracellular vesicles Glycoproteomics Biomarker 
ProteomicsDiscovery and validation of serum glycoprotein biomarker panel for detection of high grade serous ovarian cancer
We aimed to discover and validate a panel of serum biomarkers for high grade serous ovarian cancer (HGSOC) using our lectin-magnetic bead array-coupled proteomics platform. Serum from age-matched women with HGSOC, benign tumours or healthy controls were analysed in discovery (UKCTOCS, n=30 and UKOPS...
ORGANISM(S): Homo Sapiens 
2024-08-06 | PXD033108 | panorama
ProteomicsMulti-omics biomarker pipeline reveals elevated levels of protein-glutamine gamma-glutamyltransferase 4 in seminal plasma of prostate cancer patients
Prostate-specific antigen, a blood serum biomarker of prostate cancer, lacks specificity and prognostic significance, so considerable efforts are devoted to developing novel biomarkers. Seminal plasma, due to its proximity to prostate, is a promising fluid for biomarker discovery and non-invasive di...
ORGANISM(S): Homo sapiens (Human) 
2019-08-02 | PXD007657 | Pride
Prostate cancer  biomarker discovery  seminal plasma  proteomics  mass spectrometry  selected reaction monitoring  tgm4  protein-glutamine gamma-glutamyltransferase 4 
ProteomicsBiomarkers for Cervical Cancer. iTRAQ Discovery.
We developed a discovery-validation mass-spectrometry based pipeline to identify a set of proteins that are regulated in serum of patients with cervical intraepithelial neoplasia (CIN) and squamous cell cervical cancer using isobaric Tags for Relative and Absolute Quantitation (iTRAQ®), label-free ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079925 | MassIVE
Sort   by:  
 Page size