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MetabolomicsTowards engineering ectomycorrhization into switchgrass bioenergy crops via a lectin receptor-like kinase
Soil-borne microbes can establish compatible relationships with host plants, providing a large variety of nutritive and protective compounds in exchange for photosynthesized sugars. However, the molecular mechanisms mediating the establishment of these beneficial relationships remain unclear. Our pr...
2021-08-11 | MTBLS2597 | MetaboLights
TranscriptomicsCharacterization of Nicotiana attenuata plants with reduced expression of lectin receptor kinase 1 (ir-lecRK1 plants).
Identification of transcripts that change expression in Nicotiana attenuata plants with reduced expression of lectin receptor kinase 1 after elicitation with oral secretions of Manduca sexta larvae. Gene expression in leaves of Nicotiana attenuata wild type and ir-lecRK1 plants was measured at 1 hou...
ORGANISM(S): Nicotiana attenuata 
2011-11-23 | E-GEOD-29905 | biostudies-arrayexpress
ProteomicsA Bacterial Mannose Binding Lectin as a Tool for the Enrichment of C-and O- Mannosylated Peptides
C-mannosylated peptides are easily detected by mass spectrometry (MS) from purified proteins but not from complex biological samples. Enrichment of specific glycopeptides by lectin affinity prior to MS analysis has been widely applied to support glycopeptide identification, but was up till now not a...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-05-31 | PXD031484 | Pride
Glycosylation Proteomics O-mannosylation N-linked glycosylation Lc-msms Lectin C-mannosylation 
ProteomicsThe plasma proteins from human multiple myeloma was enriched by lectin AANL6 and identified by LC-MS/MS
Lectin is widely used to enrich glycoconjugates carrying glycans and to identify the abnormal glycosylated proteins in tumor with mass spectrometry, which is a useful tool for cancer diagnosis and prognosis monitoring. In our previously reported, we identified a novel lectin AANL from Agrocybe aeger...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD027111 | Pride
Lectin aanl6 Mm Human Plasma Lc-ms/ms 
TranscriptomicsExpression data from peritoneal macrophages stimulated with trehalose-6,6'-dimycolate (TDM)
Macrophage-inducible C-type lectin (Mincle, Clec4e) is a pathogen sensor that recognizes pathogenic fungi and Mycobactrium tuberculosis. We perfomed microarray analysis using peritoneal macrophages stimulated with TDM, a mycobacterial cell wall glycolipid that is known to be a Mincle ligand. Many ch...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52338 | biostudies-arrayexpress
ProteomicsProteome analysis of serum proteins enriched by lectins
Serum proteins enriched by 37 different lectins were analyzed by LC-MS/MS. It was found that the enrichment process with Solanum tuberosum lectin (STL) and Lycopersicon esculentum lectin (LEL) detected many trace proteins in the serum. In addition, combinations of lectins were examined, and the comb...
ORGANISM(S): Homo Sapiens (human) Gallus Gallus Rattus Norvegicus Ovis Aries Cellular Organisms Capra Hircus Bos Taurus Mus Musculus (mouse) 
2024-02-23 | PXD047848 | JPOST Repository
ProteomicsLectin-Fc(IgG2a) fusion proteins binding to the cell wall of C. albicans cause structural, metabolic, oxidative, and other pleiotropic effects
Candida albicans, an opportunist fungal pathogen ranked top among those causing hospital-acquired infections, exhibits diverse virulence factors aiding its survival within the human body. The rise of multidrug resistance (MDR) in C. albicans requires urgent development of new alternative antifungal ...
ORGANISM(S): Candida albicans (Yeast) 
2026-04-06 | PXD067198 | Pride
Candida albicans. lectin-fc Antifungal effects 
ProteomicsCombined Antibody/Lectin-Enrichment Identifies Extensive Changes in the O-GlcNAc Subproteome Upon Oxidative Stress
O-GlcNAc is thought to regulate proteins in a mannaer analogous to other PTMs, modulating cellular functions including the cellular stress response. The aim of this study was to identify specific cellular networks and protein complexes that are differentially O-GlcNAcylated and/or expressed upon acu...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-29 | PXD000849 | Pride
Oxidative stress Affinity chromatography Silac O-glcnac 
ProteomicsDiscovery and validation of serum glycoprotein biomarker panel for detection of high grade serous ovarian cancer
We aimed to discover and validate a panel of serum biomarkers for high grade serous ovarian cancer (HGSOC) using our lectin-magnetic bead array-coupled proteomics platform. Serum from age-matched women with HGSOC, benign tumours or healthy controls were analysed in discovery (UKCTOCS, n=30 and UKOPS...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD032299 | Pride
Ovarian cancer screening Stl Glycosylation Lemba Lectin 
ProteomicsAn unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase
N-acetylgalactosaminyl transferases (GalNAc-Ts) initiate mucin-type O-glycosylation, an abundant and complex post-translational modification that regulates host-microbe interactions, tissue development, and metabolism. GalNAc-Ts contain a C-terminal lectin domain consisting of three homologous repea...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD047845 | Pride
Muc1 O-glycosylation Structure Lectin domain Substrate specificity 
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