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TranscriptomicsSessile serrated adenomas and conventional adenomas of the colon
Sessile serrated adenomas are now recognized as precursor lesions of a substantial subset of colorectal cancers arising via a so-called “serrated pathway”. However, their biological markers remain to be defined. The aim of our study was to identify differentially expressed genes in sessile serrated ...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12514 | biostudies-arrayexpress
ProteomicsProteome analysis of formalin-fixed paraffin-embedded colorectal adenomas reveals the heterogeneous nature of Traditional Serrated Adenoma compared to the other colorectal adenomas
Traditional serrated adenoma (TSA) remains the least understood of all the colorectal adenomas although these lesions have been associated with a significant cancer risk- twice that of the conventional adenoma (CAD) and of the sessile serrated adenoma (SSA/P). This study was performed to investigat...
ORGANISM(S): Homo sapiens (Human) 
2020-01-21 | PXD014511 | Pride
Colon adenoma  label free quantification  proteomics  formalin-fixed paraffin-embedded  ffpe  sessile serrated adenoma  traditional serrated adenoma  orbitrap fusion 
GenomicsDiscovery of traditional serrated adenoma by using DSP
Discovery of traditional serrated adenoma by using DSP
PRJEB60272 | ENA
TranscriptomicsDiscovery of traditional serrated adenoma by using DSP
To further characterized the serrated pathway, we used the novel Digital Spatial Profiling (DSP) technology and its mRNA Cancer Transcriptome Atlas (CTA) panel, which includes over 1800 target gene, to investigate the underlying gene expression changes and pathways involved in sessile serrated lesio...
ORGANISM(S): Homo sapiens 
2023-12-31 | E-MTAB-12465 | biostudies-arrayexpress
TranscriptomicsDNA methylation changes in advanced sessile serrated adenomas that precede progression to dysplasia
The CpG island methylator phenotype is common in both BRAF mutant colorectal cancer and their precursors, the sessile serrated adenoma (SSA). SSAs acquire dysplasia immediate prior to progressing to invasive cancer. Here we examine the methylome of the remnant non-dysplastic portion of dysplastic se...
ORGANISM(S): Homo sapiens 
2019-07-11 | E-MTAB-7854 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing analysis of 5' capped RNAs identifies novel differentially expressed genes in sessile serrated colon polyps (SSPs)
RNA-sequencing of SSP RNA from patients with serrated polyposis syndrome identifies VSIG1 and MUC17 as potential diagnostic markers for SSPs 5' capped RNA from seven ascending SSPs, six patient matched uninvolved right colon and two normal right colon samples was used for RNA sequencing (15 samples ...
ORGANISM(S): Homo sapiens 
2014-04-29 | E-GEOD-46513 | biostudies-arrayexpress
UnknownRisk of Metachronous Neoplasia with High-Risk Adenoma and Synchronous Sessile Serrated Adenoma: A Systematic Review and Meta-Analysis.
Not available
S-EPMC10177994 | biostudies-literature
GenomicsSmall RNA sequencing of sessile serrated polyps identifies miRNA profile associated with colon cancer
Small RNA sequencing of sessile serrated polyps identifies miRNA profile associated with colon cancer
PRJNA485827 | ENA
GenomicsSmall RNA sequencing of sessile serrated polyps identifies miRNA profile associated with colon cancer
RNA sequencing analysis of small RNA expression in sessile serrated adenoma/polyps, hyperplastic polyps, adenomatous polyps, uninvolved colon and control colon
ORGANISM(S): Homo sapiens 
2018-10-18 | GSE118504 | GEO
TranscriptomicsGene expression analysis of microvesicular hyperplastic polyps and sessile serrated polyps/adenomas
In this study we compared gene expression of precancerous SSA/Ps and benign MVHPs with particular focus on genes involved in colorectal cancer. We also identify genes whose expression can be used to differentiate SSA/Ps and MVHPs. These results provide insight into the development of SSA/Ps and il...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-43841 | biostudies-arrayexpress
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