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ProteomicsIntegration of human microbiota (SIHUMIx) and zebrafish models reveals microbiome-mediated host responses to azoxystrobin
The gut microbiome is essential for neurodevelopment via bidirectional gut-brain axis signaling, yet environmental chemicals can potentially disrupt this communication by altering community structure and xenobiotic metabolism. In this study, we investigated whether the fungicide azoxystrobin, a know...
ORGANISM(S): Blautia producta ATCC 27340 = DSM 2950 Anaerostipes caccae Clostridium butyricum DSM 10702 Thomasclavelia ramosa Bifidobacterium longum NCC2705 Bacteroides thetaiotaomicron Lactobacillus plantarum subsp. plantarum Escherichia coli (strain K12) 
2026-04-27 | PXD070601 | Pride
Metabolomics Sihumix Zebrafish Azoxystrobin Microbiome 
GenomicsSIHUMIx community
Metatranscriptome sequencing of the extended simplified human intestinal microbiota (SIHUMIx)
PRJNA655119 | ENA
ProteomicsSimplified Human Intestinal Microbiota (SIHUMIx) LC-MS/MS dataset
Many functions in host���microbiota interactions are potentially influenced by intestinal transit times, but little is known about the effects of altered transition times on the composition and functionality of gut microbiota. To analyze these effects, we cultivated the model community SIHUMIx in bi...
ORGANISM(S): Blautia producta ATCC 27340 = DSM 2950 Lactobacillus plantarum Anaerostipes caccae DSM 14662 Clostridium butyricum DSM 10702 Escherichia coli str. K-12 substr. MG1655 Bifidobacterium longum NCC2705 Bacteroides thetaiotaomicron Erysipelatoclostridium ramosum DSM 1402 
2020-02-06 | PXD017035 | Pride
Sihumix Microbial community Bioreactor In vitro model Intestinal microbiota Metaproteomics 
UnknownEnvironmentally Relevant Concentration of Bisphenol S Shows Slight Effects on SIHUMIx.
Not available
S-EPMC7564734 | biostudies-literature
ProteomicsSearching for the small unknowns - Discovery of novel sProteins in a simplified human intestinal microbiome
The intestinal microbiota plays a crucial role in protecting the host from pathogenic microbes, in modulating immunity and in regulating metabolic processes. We use the simplified human intestinal microbiota (SIHUMIx) consisting of eight bacterial species to study potential synergistic effects with ...
ORGANISM(S): Blautia producta ATCC 27340 = DSM 2950 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) Clostridium butyricum DSM 10702 Anaerostipes caccae DSM 14662 Bifidobacterium longum NCC2705 Erysipelatoclostridium ramosum DSM 1402 Escherichia coli Lactobacillus plantarum subsp. plantarum 
2021-09-09 | PXD020005 | Pride
Small proteins (sproteins)  sihumix  human gut microbiome  proteogenomics  metatranscriptomics  metaproteomics 
UnknownFollowing the community development of SIHUMIx - a new intestinal in vitro model for bioreactor use.
Not available
S-EPMC7524388 | biostudies-literature
ProteomicsChemical mixture effects on the simplified human intestinal microbiota (SIHUMIx): Assessing Bisphenols and PFAS at environmentally realistic concentrations
The gut microbiota in our intestinal tract metabolizes non-digestible compounds into essential nutrients and signaling molecules (i.e. short-chain fatty acids), affecting our immune system and the development of various human diseases. Ingested environmental contaminants (xenobiotics) can disrupt th...
ORGANISM(S): Blautia producta ATCC 27340 = DSM 2950 Anaerostipes caccae Clostridium butyricum DSM 10702 Escherichia coli str. K-12 substr. MG1655 Bacteroides thetaiotaomicron Bifidobacterium longum subsp. longum Erysipelatoclostridium ramosum DSM 1402 Lactobacillus plantarum subsp. plantarum 
2024-06-13 | PXD048273 | Pride
Scfa Continuous bioreactor model system Bisphenols Gut microbiota Pfas Microbiome-dependent toxicity Metaproteomics 
UnknownThe Simplified Human Intestinal Microbiota (SIHUMIx) Shows High Structural and Functional Resistance against Changing Transit Times in In Vitro Bioreactors.
Not available
S-EPMC6956075 | biostudies-literature
ProteomicsSmall proteins in a simplified human gut microbiome
Small proteins (sProteins) with a size of 100 amino acids and less are involved in major biological processes and play an important role in different bacteria. Despite the increasing interest in them, the data on sProteins in bacterial communities, like the human gut microbiome is sparse. A reason f...
ORGANISM(S): Blautia producta ATCC 27340 = DSM 2950 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) Anaerostipes caccae DSM 14662 Clostridium butyricum DSM 10702 Escherichia coli str. K-12 substr. MG1655 Bifidobacterium longum NCC2705 Erysipelatoclostridium ramosum DSM 1402 Lactobacillus plantarum subsp. plantarum 
2020-01-07 | PXD016298 | Pride
Sihumix Small proteins Lc-ms/ms Metaproteomics 
ProteomicsHigh-throughput screening of effects of 90 xenobiotics on the Simplified Human Gut Microbiota Model (SIHUMIx): A Metaproteomic and Metabolomic Study
The human gut microbiota is a complex microbial community with critical functions for the host, including the transformation of various chemicals. While effects on microorganisms has been evaluated using single-species models, their functional effects within more complex microbial communities remain...
ORGANISM(S): Blautia producta ATCC 27340 = DSM 2950 Lactobacillus plantarum Anaerostipes caccae Clostridium butyricum DSM 10702 Escherichia coli str. K-12 substr. MG1655 Bifidobacterium longum NCC2705 Bacteroides thetaiotaomicron Erysipelatoclostridium ramosum DSM 1402 
2024-02-21 | PXD047410 | Pride
Microbiome-mediated toxicity Metabolomics Chemical-microbe interaction Chemical screening Sihumix Metaproteomics 
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