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GenomicsA long noncoding RNA regulates sister chromatid cohesion [ChIP-seq]
Long noncoding RNAs (lncRNAs) have appeared to be involved in the most diverse cellular processes through multiple mechanisms. Here we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), transcriptionally activated by MYC, which is upregulated in multiple ca...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-81600 | biostudies-arrayexpress
TranscriptomicsA long noncoding RNA regulates sister chromatid cohesion [microarray]
Long noncoding RNAs (lncRNAs) have appeared to be involved in the most diverse cellular processes through multiple mechanisms. Here we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), transcriptionally activated by MYC, which is upregulated in multiple ca...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-81599 | biostudies-arrayexpress
TranscriptomicsA long noncoding RNA regulates sister chromatid cohesion [RNA-seq]
Long noncoding RNAs (lncRNAs) have appeared to be involved in the most diverse cellular processes through multiple mechanisms. Here we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), transcriptionally activated by MYC, which is upregulated in multiple ca...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-81601 | biostudies-arrayexpress
Proteomics,MultiomicsSNW1 is required for sister chromatid cohesion
Although splicing is essential for the expression of most eukaryotic genes, inactivation of splicing factors causes specific defects in mitosis. The molecular cause of this defect is unknown. Here we show that the spliceosome subunits SNW1 and PRPF8 are essential for sister chromatid cohesion in hum...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-02 | MSV000080878 | MassIVE
GenomicsA long noncoding RNA regulates sister chromatid cohesion
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-81602 | biostudies-arrayexpress
TranscriptomicsProtein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I
Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous non-sister chromatids, which creates chiasmata and therefore bivalent chromosomes. Destruction of sister chromatid cohesion along chromosome arm...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4791 | biostudies-arrayexpress
TranscriptomicsUBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency,...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-59376 | biostudies-arrayexpress
ProteomicsSNW1 is required for sister chromatid cohesion
Although splicing is essential for the expression of most eukaryotic genes, inactivation of splicing factors causes specific defects in mitosis. The molecular cause of this defect is unknown. Here we show that the spliceosome subunits SNW1 and PRPF8 are essential for sister chromatid cohesion in hum...
ORGANISM(S): Homo sapiens (Human) 
2016-06-29 | PXD001249 | Pride
Pre-mrna splicing Snw1 Mitosis Cell cycle Sister chromatid cohesion 
GenomicsSister chromatid cohesion halts DNA loop expansion
Sister chromatid cohesion halts DNA loop expansion
PRJNA993572 | ENA
TranscriptomicsPost-replicative formation of cohesion is required for repair and induced by a single DNA break
Sister chromatid cohesion, established during replication by the protein complex Cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally cohesion formation is strictly limited to the S-phase of the cell cycle, but DSBs can trigger cohesion also after DNA ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-8270 | biostudies-arrayexpress
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