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ProteomicsSMARCA2, VHL Binary and Ternary Complex formation with ACBi1, PROTAC1, and PROTAC2
Interrogration of impacts on Hydrogen Deuterium Exchange of ligand binding using heterobifunctional molecules ACBi1(SiTX-0038406), PROTAC1(SiTX-0038404) and PROTAC2(SiTX-0038405) on target proteins SMARCA2 and VHL both in the binary and Ternary modes.
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD033849 | Pride
Hdx-ms 
ProteomicsSelective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
The mammalian SWI/SNF helicase SMARCA4 is frequently mutated in cancer and inactivation results in a cellular dependence on its paralog, SMARCA2, thus making SMARCA2 an attractive synthetic lethal target. However, published data indicates that achieving a high degree of SMARCA2 selectivity is likely...
ORGANISM(S): Homo sapiens (Human) 
2022-09-22 | PXD036865 | Pride
Human Ubiquityome Tmt Isobaric labeling Degrader Proteome Protac 
GenomicsGenome binding of SMARCA2 and SMARCA4 in lung cancer cells reconstituted with SMARCA4 WT with and without SMARCA2 depletion
Genome binding of SMARCA2 and SMARCA4 in lung cancer cells reconstituted with SMARCA4 WT with and without SMARCA2 depletion
PRJNA613396 | ENA
ProteomicsSMARCA2/4 degradation tails mediate recruitment of two different E3 ligases 
In this work, we characterise novel SMARCA2/4 degraders using a robust cell biology and structural workflow and reveal for the first time, the recruitment of two E3 ligase substrate receptors: FBXO22 and DCAF16 by the same degradation tail. Furthermore, we were able to chemically fine-tune this dual...
ORGANISM(S): Homo sapiens (Human) 
2026-05-16 | PXD065523 | Pride
E3 ligases  Smarca2/4 Protein degrader 
UnknownComplex alternative splicing of the smarca2 gene suggests the importance of smarca2-B variants.
Not available
S-EPMC3148773 | biostudies-literature
GenomicsHeterozygous mutations in SMARCA2 lead to impaired neurogenesis due to global retargeting of SMARCA4
Heterozygous mutations in SMARCA2 lead to impaired neurogenesis due to global retargeting of SMARCA4
PRJNA505818 | ENA
UnknownSelective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
Not available
S-EPMC9649729 | biostudies-literature
ProteomicsSMARCA2/4 degradation tails mediate recruitment of two different E3 ligases 
In this work, we characterise novel SMARCA2/4 degraders using a robust cell biology and structural workflow and reveal for the first time, the recruitment of two E3 ligase substrate receptors: FBXO22 and DCAF16 by the same degradation tail. Furthermore, we were able to chemically fine-tune this dual...
ORGANISM(S): Homo sapiens (Human) 
2026-05-16 | PXD065445 | Pride
Smarca2/4 E3 ligases  Protein degrader 
UnknownHeterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.
Not available
S-EPMC7291823 | biostudies-literature
GenomicsChromatin accessibility in response to knockdown of GLI1 and SMARCA2 in GLI1-mediated gene expression.
Chromatin accessibility in response to knockdown of GLI1 and SMARCA2 in GLI1-mediated gene expression.
PRJNA601229 | ENA
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