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TranscriptomicssnRNA-seq of whole hearts from adult BL6 mice
We used snRNA-seq to investigate an entire adult mammalian heart of BL6 mice. Whole hearts were harvested from 4 male mice (12 weeks) after cervical dislocation. The hearts were pooled and nuclei isolated using the Nuclei PURE Prep isolation kit (Sigma-Aldrich, Darmstadt, Germany) according to the m...
ORGANISM(S): Mus musculus 
2020-03-16 | E-MTAB-8848 | biostudies-arrayexpress
TranscriptomicsMultiple roles for LEC in initiation and elongation phases of snRNA gene transcription
The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to unique aspects of their promoter structure, selectivity for either RNA Polymerase (Pol) II or III and a unique mechanism of termination that is tightly linked with the prom...
ORGANISM(S): Homo sapiens 
2013-08-08 | E-GEOD-47938 | biostudies-arrayexpress
TranscriptomicssnRNA-seq of whole hearts from adult fzt:DU mice
We used snRNA-seq to investigate for the first time an entire adult mammalian heart. To avoid potential aberrations due to inbreeding, we relied on an outbred mice strain (Fzt:DU) (Dietl, G.; Langhammer, M.; Renne, U. Model simulations for genetic random drift in the outbred strain Fzt:DU. Arch. Ani...
ORGANISM(S): Mus musculus 
2020-02-22 | E-MTAB-8751 | biostudies-arrayexpress
TranscriptomicsSHAPE-Seq of human U2 snRNA and U4 pre-snRNA
Spliceosomal snRNA are key components of small nuclear ribonucleoprotein particles (snRNPs), the building blocks of the spliceosome. The biogenesis of snRNPs is a complex process involving multiple cellular and subcellular compartments, the details of which are yet to be described. In short, the snR...
ORGANISM(S): Homo sapiens 
2023-09-08 | E-MTAB-13248 | biostudies-arrayexpress
TranscriptomicsThe little elongation complex (LEC) regulates small nuclear RNA transcription
The Eleven-nineteen Lysine-rich Leukemia (ELL)-containing Super Elongation Complex (SEC) containing P-TEFb is a key regulator in the expression of HOX genes in Mixed Lineage Leukemia (MLL)-based leukemia. We have identified an SEC-like complex in Drosophila, as well as a distinct ELL-containing comp...
ORGANISM(S): Drosophila melanogaster 
2011-12-22 | E-GEOD-32120 | biostudies-arrayexpress
UnknownDissecting the molecular landscape of Parkinson's disease and Parkinson's disease dementia using highly efficient snRNA-seq (HIF-snRNA-seq).
Not available
S-EPMC11908213 | biostudies-literature
TranscriptomicssnRNA-seq data from single cell multiomics (paired snRNA-seq+snATAC-seq) of human colorectal cancer liver metastatic samples
These samples are part of a study investigating cancer cell plasticity in colorectal cancer metastasis. Tumour microenvironment cell types and cancer cell states were identified using 10x Genomics Multiome (paired snRNA-seq + snATAC-seq). snRNA-seq data is uploaded here.
ORGANISM(S): Homo sapiens 
2025-04-22 | E-MTAB-13651 | biostudies-arrayexpress
TranscriptomicssnRNA-seq for Macaque LIP
snRNA-sequencing data for macaque LIP area. We isolated single nuclei from the LIP region. annotating the dataset with the canonical classification and integration with other datasets.
ORGANISM(S): Macaca fascicularis 
2026-05-31 | E-MTAB-13364 | biostudies-arrayexpress
TranscriptomicsMultiome RNA+ATAC on human PBMCs (snRNA-seq data)
We generated Multiome RNA+ATAC data from the same cell from human PBMC. This served as a gold benchmark for a novel integration method for multi-omics data that we developed.
ORGANISM(S): Homo sapiens 
2021-12-02 | E-MTAB-11225 | biostudies-arrayexpress
GenomicsscRNA-Seq and snRNA-Seq in human adipose tissue
scRNA-Seq and snRNA-Seq in human adipose tissue
PRJNA782630 | ENA
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