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MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_MALDI imaging]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12601 | MetaboLights
MetabolomicsSpatial and Untargeted Metabolomics Define Location- and Histology-Specific Metabolic Reprogramming in Colorectal Cancer

Colorectal cancer (CRC) exhibits profound molecular heterogeneity based on primary tumor location. A comprehensive understanding of the spatially resolved metabolic differences between right-sided (RCC) and left-sided (LCC) carcinomas remains elusive. Here, to eliminate the influence of inter-ind...

2026-03-24 | MTBLS13729 | MetaboLights
MetabolomicsSpatial metabolomics shows contrasting phosphonolipid distributions in tissues of marine bivalves

Lipids are an integral part of cellular membranes, vary between species, and allow cells to alter stiffness, permeability and curvature. Among lipids, phosphonolipids uniquely contain a phosphonate bond between carbon and phosphorous. Despite this distinctive biochemical characteristic, few model...

2022-06-26 | MTBLS2960 | MetaboLights
MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_LCM]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12561 | MetaboLights
TranscriptomicsGBM-Space: Spatial Transcriptomic Profiling of Glioblastoma (10x Genomics - Visium)
Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single cell and spatial multi-omic a...
ORGANISM(S): Homo sapiens 
2026-09-12 | E-MTAB-17164 | biostudies-arrayexpress
ProteomicsMultimodal single-cell resolved spatial proteomics reveal pancreatic tumor heterogeneity
In this study, we offer a competitive solution for uncovering the comprehensive heterogeneity of tissue context.
ORGANISM(S): Mus Musculus 
PXD038882 |
Transcriptomics14 primary formalin fixated paraffin embedded (FFPE) PDAC tissue slices from 14 patients without pretreatment were analyzed using spatial transcriptomics
Pancreatic ductal adenocarcinoma (PDAC) exhibits profound molecular heterogeneity and poor prognosis, necessitating novel tailored therapies. The basal and classical molecular subtypes of PDAC - driven by glycolysis versus lipid metabolism - have distinct prognostic implications. Spatial transcripto...
ORGANISM(S): Homo sapiens 
2026-09-30 | E-MTAB-15702 | biostudies-arrayexpress
TranscriptomicsGeoMX spatial transcriptomics of diffuse pleural mesothelioma: impact of CDKN2A deletion
We compared GeoMX spatially resolved gene expression profiles of diffuse pleural mesothelioma (DPM) samples with or without somatic CDKN2A deletion. 5 CDKN2Adel and 4 WT DPM samples were analyzed. A total of 202 Areas Of Illumination (AOIs) were transcriptionally profiled, of which 140 Sarcomatoid-...
ORGANISM(S): Homo sapiens 
2026-05-01 | E-MTAB-15378 | biostudies-arrayexpress
ProteomicsSpatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma
The inter-patient variability of tumor proteomes has been investigated on a large scale but many tumors display also intra-tumoral heterogeneity (ITH) regarding morphological and genetic features. To what extent the local proteome of tumors intrinsically differs remains largely unknown. Here, we use...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-01-24 | PXD007052 | Pride
Intra-tumoral heterogeneity Liver Hepatocellular carcinoma 
GenomicsSpatial transcriptomics reveals heterogeneity of odontogenic keratocysts
Spatial transcriptomics reveals heterogeneity of odontogenic keratocysts
PRJNA1022785 | ENA
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