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ProteomicsMultidimensional proteomic landscape of intercellular signaling in pancreatic cancer
We developed a multidimensional proteomic strategy to profile the glycosylated secreted and plasma membrane (S-PM) proteome of 100 human pancreatic tissue samples to an unprecedented depth, define cell-type origins of these S-PM proteins through spatial proteomics, and identify potential paracrine c...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-08-19 | PXD048644 | Pride
Human Spatial proteomics Phosphoproteomics Pancreatic cancer Shedding Prm Glycoproteomics Mouse Dda Lc-ms/ms 
ProteomicsSpatial Proteomics Profiling of Vascular Smooth Muscle Cells and Atherosclerotic Plaques in a Diabetic Atherosclerosis Mouse Model
This project presents a spatial proteomic investigation of vascular smooth muscle cells (VSMCs) and atherosclerotic plaque regions in a diabetic mouse model of atherosclerosis (DMAS). Using ApoE-/- mice fed with a high-fat diet and treated with low-dose streptozotocin (STZ) to induce a diabetic phen...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD063231 | Pride
Diabetes mellitus  atherosclerosis  spatial proteomic technology 
ProteomicsProteomic Sensors for Quantitative, Multiplexed, and Spatial Monitoring of Kinase Signaling
Proteomic Kinase Activity Sensors (ProKAS) is a new technology developed to allow for quantitative and multiplexed analyses of kinase signaling in living cells with spatial resolution. Kinase sensors are expressed in cells as part of a ProKAS construct, which uses signal peptides to localize to spec...
ORGANISM(S): Homo sapiens (Human) 
2025-10-02 | PXD065795 | Pride
Proteomics atr atm chk1 dna damage genome maintenance signaling phosphoproteomics prm 
ProteomicsSpatial Proteomics of a human brain tumour
The spatial organisation of Cellular protein expression profiles within tissues determines cellular function and are key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for unbiased, quantitative technology capable of mapping prote...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD039159 | Pride
Spatial Laser capture microdissection Proteomics 
GenomicsThe development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment
The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment
PRJNA1217386 | ENA
ProteomicsSpatial Proteomics of a Human Brain Tumour
The spatial organisation of Cellular protein expression profiles within tissues determines cellular function and are key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for unbiased, quantitative technology capable of mapping prote...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD039398 | Pride
Spatial Laser capture microdissection Proteomics Maldi imaging 
ProteomicsDeep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury
As a primary target of SARS-CoV-2, lung exhibits heterogeneous histopathological changes following infection. However, comprehensive insight into their protein basis with spatial resolution remains deficient, which hinders further understanding of COVID-19-related pulmonary injury. Here, we generate...
ORGANISM(S): Homo sapiens (Human) 
2024-01-22 | PXD043807 | Pride
Covid-19 Laser microdissection Pathology Lung Autopsy Spatial proteomics 
ProteomicsA standardized and reproducible workflow for membrane glass slides in routine histology and spatial proteomics
Defining the molecular phenotype of single cells in-situ is essential for understanding tissue heterogeneity in health and disease. Powerful imaging technologies have recently been joined by spatial omics technologies, promising unparalleled insights into the molecular landscape of biological sample...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040281 | Pride
Antigen retrieval Spatial proteomics Deep visual proteomics Glycerol Membrane slides Histology Proteomics Heat-induced epitope retrieval Laser microdissection 
ProteomicsUltra-fast and deep spatial proteomic technology enables topographic mapping of human brain tumors
Spatial proteomics is essential for resolving molecular heterogeneity and tissue microenvironment, yet it remains constrained by trade‑offs among spatial resolution, analytical throughput, and proteome depth. Here we present SMID‑MOSF, an ultra‑trace and rapid sample preparation strategy based on ma...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD076766 |
UnknownIdentifying perturbations that boost T-cell infiltration into tumours via counterfactual learning of their spatial proteomic profiles.
Not available
S-EPMC11922765 | biostudies-literature
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