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xref:PubMed:40196518 (1)

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Loss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors

PRJNA811500 | ENA

Loss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors

Heat Shock Protein 90 inhibitors (HSP90i) have shown encouraging activity in EML4-ALK+ non-small cell lung cancer (NSCLC) patients but clinical responses have been heterogeneous. It has been suggested that distinct EML4-ALK variants may have a differential impact on the response to HSP90 inhibition....

ORGANISM(S): Homo sapiens

2025-02-01 | GSE197655 | GEO

Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY

SPINDLY (SPY) in Arabidopsis thaliana is a novel nucleocytoplasmic protein O-fucosyltransferase (POFUT), which regulates diverse developmental processes. Sequence analysis indicates that AtSPY is distinct from ER-localized POFUTs and contains N-terminal tetratricopeptide-repeats (TPRs) and a C-termi...

ORGANISM(S): Nicotiana tabacum (Common tobacco)

2023-02-28 | PXD040480 | Pride