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ProteomicsLoss of ST8SIA6 Promotes Colorectal Cancer Metastasis by Enhancing MUC16-Integrin β4 Signaling
This project investigates the functional role of the α2,8-sialyltransferase ST8SIA6 in the progression and metastasis of colorectal cancer. Through the use of Siglec-7-based enrichment and subsequent mass spectrometry analysis, MUC16 was identified as a primary glycoprotein affected by the loss of S...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD077963 | Pride
Colorectal cancer  metastasis  st8sia6  muc16  integrin β4  glycosylation  src/fak signaling 
UnknownCutting Edge: Enhanced Antitumor Immunity in ST8Sia6 Knockout Mice.
Not available
S-EPMC9012686 | biostudies-literature
UnknownBioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer.
Not available
S-EPMC8953768 | biostudies-literature
GenomicsST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic Th1 and Th17 programs
ST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic Th1 and Th17 programs
PRJNA1419813 | ENA
GenomicsILMN_2300_PiganelliJon_totalRNAseq36_Oct2024. RNA Sequessing of Pocinr Kidney Endothelial cells transfected with Control GFP and ST8Sia6 Plasmid
ILMN_2300_PiganelliJon_totalRNAseq36_Oct2024. RNA Sequessing of Pocinr Kidney Endothelial cells transfected with Control GFP and ST8Sia6 Plasmid
PRJNA1257413 | ENA
UnknownST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6.
Not available
S-EPMC7515456 | biostudies-literature
TranscriptomicsILMN_2300_PiganelliJon_totalRNAseq36_Oct2024. RNA Sequessing of Pocinr Kidney Endothelial cells transfected with Control GFP and ST8Sia6 Plasmid
To check the effectes of ST8Sia6 overexpression we performed total RNS sequesnning in porcine kidney endothelial cells to understand the biological functions of DEGs associated with ST8Sia6 overexpression in porcine kidney endothelial cells upon co-culture with human PBMCs, transcriptomic analysis w...
ORGANISM(S): Sus scrofa 
2025-05-05 | GSE296057 | GEO
UnknownST8SIA6-AS1 contributes to hepatocellular carcinoma progression by targeting miR-142-3p/HMGA1 axis.
Not available
S-EPMC9837176 | biostudies-literature
UnknownST8Sia6 overexpression protects pancreatic β cells from spontaneous autoimmune diabetes in nonobese diabetic mice.
Not available
S-EPMC12321382 | biostudies-literature
UnknownST8SIA6-AS1 serves as a prognostic biomarker in cancer and exhibits oncogenic properties in prostate cancer.
Not available
S-EPMC12634032 | biostudies-literature
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