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TranscriptomicsDifferential DNA Methylation Patterns Define Status Epilepticus and Epileptic Tolerance
Comparison of methylation profiles in the CA3 region of the mouse hippocampus in epileptic tolerance and status epilepticus.
ORGANISM(S): Mus musculus 
2012-02-09 | E-MEXP-3503 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of rat hippocampus after status epilepticus induced by amygdala stimulation
MicroRNAs (miRNAs) are small and endogenously expressed non-coding RNAs that negatively regulate the expression of protein-coding genes at the translational level. Emerging evidence suggests that miRNAs play critical roles in central nervous system under physiological and pathological conditions. Ho...
ORGANISM(S): Rattus norvegicus 
2014-01-06 | E-GEOD-50940 | biostudies-arrayexpress
TranscriptomicsmiRNA transcription profiling in Status Epilepticus Induced Epileptogenic Process
miRNA array comparing the transcription profile of control rats and rats after intra-hippocampal pilocarpine-induced Status Epilepticus (PILO-SE).
ORGANISM(S): Rattus norvegicus 
2016-04-28 | E-MTAB-4633 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of a mouse model of epileptic tolerance
Microarray analysis was performed 24 hr after status epilepticus in mice that had received previously either siezure preconditioning (tolerance) or sham-preconditioning (injury). Transcriptional changes in the CA3 subfield of the hippocampus were analyzed using the Affymetric Mouse 430_2 Genechip.
ORGANISM(S): Mus musculus 
2009-05-22 | E-TABM-709 | biostudies-arrayexpress
TranscriptomicsmicroRNAs profiling in hippocampal cells of Self-Sustaining Status Epilepticus (SSSE) mouse model
Status Epilepticus (SE) is induced in mice (C57Bl/6J) through electrical stimulation (90min, 100 ms trains of 1 ms, 2 trains per 1 s, 250 μA peak current intensity). RNA was extracted from the hippocampi at 24 h and 28 d after induction. In wild-type RNA was extracted on the 22nd day. microRNA expre...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-51842 | biostudies-arrayexpress
Transcriptomicsepileptogenesis
experimental group and control group in rat post-status epilepticus model. Keywords: parallel sample
ORGANISM(S): Rattus norvegicus 
2003-10-30 | E-GEOD-785 | biostudies-arrayexpress
TranscriptomicsNRSF mediated epigenetic mechanisms of ion channel dysfunction in experimental temporal lobe epilepsy [Control vs. Kainate, scrambled ODNs]
Oligodeoxynucleotides used to prevent NRSF binding to NRSE containing genes were utilized to prevent many kainate induced status epilepticus changes in gene expression. Total RNA recovered from CA1 of hippocampus of rats receiving scrambled, and saline(controls) or kainate injections (induced status...
ORGANISM(S): Rattus norvegicus 
2014-08-12 | E-GEOD-22896 | biostudies-arrayexpress
TranscriptomicsNRSF mediated epigenetic mechanisms of ion channel dysfunction in experimental temporal lobe epilepsy [Kainate, NRSE ODNs vs. Kainate, scrambled ODNs]
Oligodeoxynucleotides used to prevent NRSF binding to NRSE containing genes were used to prevent many kainate induced status epilepticus changes in gene expression. Total RNA recovered from CA1 of hippocampus of rats receiving scrambled or NRSE oligodeoxynucleotides, and kainate injections (induced ...
ORGANISM(S): Rattus norvegicus 
2014-08-12 | E-GEOD-22897 | biostudies-arrayexpress
TranscriptomicsNRSF mediated epigenetic mechanisms of ion channel dysfunction in experimental temporal lobe epilepsy [Control vs. Kainate, NRSE ODNs]
Oligodeoxynucleotides used to prevent NRSF binding to NRSE containing genes were utilized to prevent many kainate induced status epilepticus changes in gene expression. Total RNA recovered from CA1 of hippocampus of rats receiving scrambled or NRSE oligodeoxynucleotides, and saline(controls) or kain...
ORGANISM(S): Rattus norvegicus 
2014-08-12 | E-GEOD-22894 | biostudies-arrayexpress
TranscriptomicsRat MeDIP Array, naïve, epileptic, and adenosine treated
Epilepsy causes altered gene expression; transient adenosine treatment inhibits progression of epileptogenesis Hippocampus of epileptic rat is hypermethylated compared to naïve; adenosine treatment causes hypomethylation Metylation state in epileptic rats (9 weeks post kainic acid induced status epi...
ORGANISM(S): Rattus rattus 
2013-09-05 | E-GEOD-45932 | biostudies-arrayexpress
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