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ProteomicsStructural perturbation at the N-terminal domain of human phosphoglycerate kinase 1 reduces the kinetic stability and unfolding cooperativity of a two-domain enzyme
Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer development and rare genetic diseases that affect several of their features. To investigate how mutations affect hPGK1 foldin...
ORGANISM(S): Homo sapiens (Human) 
2022-11-03 | PXD035628 | Pride
Protein folding  structural perturbation  disease 
GenomicsStructural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [RCMC]
Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [RCMC]
PRJNA1133049 | ENA
GenomicsStructural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [CHiC]
Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [CHiC]
PRJNA1130516 | ENA
GenomicsStructural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [Cut&Run]
Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [Cut&Run]
PRJNA1133042 | ENA
GenomicsStructural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [RNA-seq-brain]
Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [RNA-seq-brain]
PRJNA1145434 | ENA
GenomicsStructural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [Micro-C]
Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development [Micro-C]
PRJNA1133046 | ENA
UnknownAqueous ionic liquids redistribute local enzyme stability via long-range perturbation pathways.
Not available
S-EPMC8355836 | biostudies-literature
ProteomicsProteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.
Proteins regulate biological processes by changing their structure or abundance to accomplish a specific function. In response to any perturbation or stimulus, protein structure may be altered by a variety of molecular events, such as post translational modification, protein-protein interaction, agg...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-10 | PXD031627 | Pride
Alpha-synuclein Shotgun proteomics Yeast Structural proteomics Lip-ms 
ProteomicsProteome-wide structural changes measured with 2 limited proteolysis-mass spectrometry: an advanced 3 protocol for high-throughput applications.
Proteins regulate biological processes by changing their structure or abundance to accomplish a specific function. In response to any perturbation or stimulus, protein structure may be altered by a variety of molecular events, such as post translational modification, protein-protein interaction, agg...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-10 | PXD031616 | Pride
Shotgun proteomics Human alpha-synuclein Yeast Structural proteomics Lip-ms 
GenomicsStructural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation and genomic profiling
Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation and genomic profiling
PRJNA823666 | ENA
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