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MetabolomicsUsing an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein
INTRODUCTION: The pathogenicity at differing points along the aggregation pathway of many fibril-forming proteins associated with neurodegenerative diseases is unclear. Understanding the effect of different aggregation states of these proteins on cellular processes is essential to enhance understand...
2018-06-11 | MTBLS455 | MetaboLights
TranscriptomicsAlpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization
Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutations and gene duplication/triplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movemen...
ORGANISM(S): Mus musculus 
2010-07-21 | E-GEOD-19534 | biostudies-arrayexpress
ProteomicsPost-translational modifications of MSA alpha-synuclein
LC-MS/MS analysis of post-translational modifications in alpha-synuclein of five MSA cases.
ORGANISM(S): Homo Sapiens (human) 
2020-04-09 | PXD018434 | JPOST Repository
ProteomicsIdentification of Alpha-Synuclein Interacting Synaptosomal Proteins
α-Synuclein is an abundant presynaptic protein that when aggregated and dyslocated from the synapse is associated to Parkinson’s disease and dementia. The normal presynaptic function of α-synuclein is unclear as well as the disease triggering mechanism. In order to extend the knowledge of the α-synu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2015-02-09 | PXD001462 | Pride
Aggregation Synaptosomes Protein-protein interactions Proteomics Alpha-synuclein 
TranscriptomicsTranscription profiling of transgenic mice overexpressing human alpha-synuclein under the PDGF beta promoter to wildtype littermates at 3 months and 9 months of age.
Microarray comparison of transgenic mice overexpressing human alpha-synuclein under the PDGF beta promoter to wildtype littermates at 3 months and 9 months of age. RNA was extracted from substantia nigral cells that were isolated by laser capture microdissection.
ORGANISM(S): Mus musculus 
2007-12-20 | E-MEXP-1383 | biostudies-arrayexpress
ProteomicsChemical Crosslinking of Isotopically Labeled α-Synuclein Reveals Structural Changes and the Interface of Oligomeric Species
Due to its high pharmaceutical relevance, α-synuclein is one of the best studied intrinsically disordered proteins to date. Its structural plasticity reaches from α-helical when bound to membranes through disordered in solution to β-sheet when forming amyloid fibrils. Recently the possible toxicity ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-07 | PXD027349 | Pride
Human Cross-linking mass spectrometry Α-synuclein 
TranscriptomicsSingle-cell RNA sequencing (scRNA-seq) profiles of fetal human cortical neurons
The dataset consists of single-cell RNA sequencing (scRNA-seq) profiles of fetal human cortical neurons (10 weeks gestation) under six experimental conditions: Sample 1 – Control: Untreated cells. Sample 2 – PFF treated: Cells exposed to alpha-synuclein pre-formed fibrils (PFF) for 14 days. Sample 3...
ORGANISM(S): Homo sapiens 
2026-04-09 | E-MTAB-16863 | biostudies-arrayexpress
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
ModelsMorris2009 - α-Synuclein aggregation variable temperature and pH
Morris2009 - α-Synuclein aggregation variable temperature and pH This model is described in the article: Alpha-synuclein aggregation variable temperature and variable pH kinetic data: a re-analysis using the Finke-Watzky 2-step model of nucleation and autocatalytic growth. ...
2024-09-02 | BIOMD0000000566 | BioModels
TranscriptomicsExpression data from Parkison's iPSCs with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative
A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplicati...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30792 | biostudies-arrayexpress
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