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TranscriptomicsGene Expression Analyses of Subchondral Bone in Early Experimental Osteoarthritis by Microarray
Osteoarthritis (OA) is a complex degenerative joint disease, which is not only a cartilage but also a bone disease. A better understanding of the early molecular mechanism changes of subchondral bone in vivo may contribute to elucidating the pathogenesis of OA. We used microarray technology to inves...
ORGANISM(S): Rattus norvegicus 
2012-12-11 | E-GEOD-30322 | biostudies-arrayexpress
ProteomicsA COMPREHENSIVE AND QUANTIFIABLE INSIGHT INTO THE PROTEOMES OF ARTICULAR CARTILAGE AND SUBCHONDRAL BONE
In this study, we used two workflows based on either pressure cycling technology (PCT) or ultrasonication (US) in combination with data independent acquisition (DIA) based mass spectrometry (MS) analysis to quantitatively assess the proteomes of articular cartilage and subchondral bone.
ORGANISM(S): Equus caballus (Horse) 
2022-10-12 | PXD025882 | Pride
Osteoarthritis Subchondral bone Cartilage Equine Spectral library 
ProteomicsActivation of Wnt/β-catenin signaling in subchondral bone osteoblast responced to hypoxia lead to osteoarthritis-like phenotype in articular chondrocyte
The crosstalk between the cartilage and subchondral bone plays a crucial role in the pathogenesis and progression of OA. The aim of this study was to identify soluble mediators released by osteoblasts that could induce the release of catabolic factors by chondrocytes. Global protein sequencing of su...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD021135 | Pride
Osteoarthritis(oa)  subchondral bone  articular cartilage  procoagulation  hypoixa  wnt pathway  β-catenin 
TranscriptomicsEquine cartilage and bone miRNA repertoires
Short-read NGS technology (SOLIDTM, Life Technologies) was used to establish a comprehensive repertoire of miRNA expressed in either equine cartilage or subchondral bone. Undamaged cartilage and subchondral bone samples from 10-month Anglo-Arabian foals affected by osteochondrosis (OC) were analyzed...
ORGANISM(S): Equus caballus 
2014-08-24 | E-MTAB-2736 | biostudies-arrayexpress
TranscriptomicsGenome-wide Expression Profiles of Subchondral Bone in Osteoarthritis
To date, all of the prior osteoarthritic microarray studies in human tissue have focused on the overlying articular cartilage, meniscus, or synovium but not the underlying subchondral bone. In our previous study, our group developed a methodology for high quality RNA isolation from site-matched cart...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-51588 | biostudies-arrayexpress
GenomicsSpatial transcriptomics reveals microenvironmental heterogeneity in osteoarthritic subchondral bone
Spatial transcriptomics reveals microenvironmental heterogeneity in osteoarthritic subchondral bone
PRJNA1508755 | ENA
GenomicsTargeting osteoblastic Mig6-EGFR signaling ameliorates osteoarthritis progression via inhibiting aberrant subchondral bone remodeling
Targeting osteoblastic Mig6-EGFR signaling ameliorates osteoarthritis progression via inhibiting aberrant subchondral bone remodeling
PRJNA1288372 | ENA
UnknownAbnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients.
Not available
S-EPMC5674679 | biostudies-literature
ProteomicsOsteoarthritis osteoblasts secretome
Osteoarthritis (OA) is the most common joint disease and this is a major cause of joint pain and disability in the aging population. Its etiology is multifactorial (i.e., age, obesity, joint injury, genetic predisposition), and the pathophysiologic process affects the entirety of the joint (Martel-P...
ORGANISM(S): Homo sapiens (Human) 
2018-03-20 | PXD008494 | Pride
Osteoarthritis Secretome Osteoblasts Matrix mineralization Non-collagenous proteins 
GenomicsCxcr2 deficiency alters transcriptional programs in articular cartilage and subchondral bone of adult male mice
Cxcr2 deficiency alters transcriptional programs in articular cartilage and subchondral bone of adult male mice
PRJNA1530436 | ENA
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