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MetabolomicsPrevotella copri mediated caffeine metabolism involves ferroptosis of osteoblasts in osteoarthritis

There is positive causality between coffee consumption and osteoarthritis (OA), however, whether gut microbiota is involved in it needs to be discussed. Here, we observed that, in caffeine consumers, fecal Prevotella copri (P. copri) abundance was positively correlated with subchondral bone mass,...

2025-03-21 | MTBLS11685 | MetaboLights
ProteomicsOsteoarthritis osteoblasts secretome
Osteoarthritis (OA) is the most common joint disease and this is a major cause of joint pain and disability in the aging population. Its etiology is multifactorial (i.e., age, obesity, joint injury, genetic predisposition), and the pathophysiologic process affects the entirety of the joint (Martel-P...
ORGANISM(S): Homo sapiens (Human) 
2018-03-20 | PXD008494 | Pride
Osteoarthritis Secretome Osteoblasts Matrix mineralization Non-collagenous proteins 
TranscriptomicsEarly Response Genes in Osteoblasts Exposed to Dynamic Fluid Flow
Cyclic mechanical loads applied to the skeleton increase bone formation. Dynamic fluid flow is a potent anabolic stimulus for cultured osteoblasts. In this study, gene profiles involved in mediating the anabolic response of MC3T3 osteoblasts to dynamic fluid flow are investigated. MC3T3 osteoblast R...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-16211 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of heterotypic interactions between cancer cells and osteoblasts in vitro
Bone is the most common site of breast cancer metastasis, and this type of metastasis is a main cause of morbidity. Because breast cancer is a heterogeneous disease, the interactions between the cancer cells and the skeletal host cells, such as osteoblasts, might be diverse. Thus far, these tumor-os...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29036 | biostudies-arrayexpress
TranscriptomicsGene expression of human paediatric osteosarcoma tumour samples relative to normal human osteoblasts
Gain or loss of genes and deregulation of gene expression can result in cumulative and progressive disruptions of normal cellular functions. Cancer-specific changes in gene expression play an essential role in cancer occurrence, and ultimately lead to cancer-related self-sufficiency in growth signal...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-12865 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stem cell-derived osteoblasts following RNAi knock down of phosphodiesterase 7 and 8A
Effects of phosphodiesterase 7 and 8A inhibition by RNA Interference on the gene expression of human mesenchymal stem cell-derived osteoblasts.
ORGANISM(S): Homo sapiens 
2008-12-12 | E-MEXP-1021 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and MCF7 mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (MCF7) and cells that represented skeletal compartments (Normal Human (NH) Osteoblasts) wer...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29032 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and SKBR3 mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (SKBR3) and cells that represented skeletal compartments (Normal Human (NH) Osteoblasts) we...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29034 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and T47D mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (T47D) and cells that represented skeletal compartments (Normal Human (NH) Osteoblasts) wer...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29035 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and HMEC mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented healthy epithelial cell compartments (HMEC - human mammary epithelial cell) and cells that represented skeletal compartments (Norm...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29030 | biostudies-arrayexpress
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