suv39h1 - OmicsDI

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Effects of SUV39H1 depletion on gene expression in HeLa cells

HeLa cells were transiently transfected with siRNA against SUV39H1, a histone H3K9 methyltransferase. Several genes were significantly up- or down-regulated. HeLa cells were transiently transfected with siRNA against SUV39H1 or negative control siRNA. Then total RNA was extracted.

ORGANISM(S): Homo sapiens

2015-08-01 | E-GEOD-59243 | biostudies-arrayexpress

Specificity, propagation and memory of pericentric heterochromatin in mouse fibroblasts

We assembled a quantitative map for the abundance and interactions of 16 factors related to PCH in living cells and found that stably bound complexes of the histone methyltransferase Suv39h1/2 demarcate the PCH state. From the experimental data we developed a predictive mathematical model that expla...

ORGANISM(S): Mus musculus

2014-08-12 | E-GEOD-58555 | biostudies-arrayexpress

Expression data from Adriamycin-treated Emu-myc; Suv39h1-/- B-cell lymphoma

Oncogene-induced senescence (OIS), a terminal cell cycle block countering (pre)neoplastic lesions, is characterised on the molecular level by trimethylated histone H3 lysine 9 (h3K9me3), a transcriptionally repressive chromatin mark linked to silencing of S-phase-promoting genes. Whether H3K9-govern...

ORGANISM(S): Mus musculus

2013-07-04 | E-GEOD-44355 | biostudies-arrayexpress

SUV39H1 Maintains Cancer Stem Cells in Glioblastoma [RNA-seq]

PRJNA1139792 | ENA

SUV39H1 Maintains Cancer Stem Cells in Glioblastoma [ATAC-seq]

PRJNA1139791 | ENA

Histone ubiquitination-methylation crosstalk involving UHRF1 and SUV39H1/2 reinforces heterochromatin states in response to DNA hypomethylation

Histone H3 mono-ubiquitination, catalyzed by the RING E3 ubiquitin ligase UHRF1, is appreciated as a docking site for DNMT1 during DNA replication to facilitate DNA methylation maintenance. Its functions beyond this are unknown. Here, we identify simultaneous increases in UHRF1-dependent H3K18ub and...

ORGANISM(S): Homo sapiens (Human)

2024-12-02 | PXD049993 | Pride