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ProteomicsHistone ubiquitination-methylation crosstalk involving UHRF1 and SUV39H1/2 reinforces heterochromatin states in response to DNA hypomethylation
Histone H3 mono-ubiquitination, catalyzed by the RING E3 ubiquitin ligase UHRF1, is appreciated as a docking site for DNMT1 during DNA replication to facilitate DNA methylation maintenance. Its functions beyond this are unknown. Here, we identify simultaneous increases in UHRF1-dependent H3K18ub and...
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD049993 | Pride
Uhrf1 Suv39h1/2 Epigenetic therapy Histone ubiquitination Dna methylation Histone methylation 
GenomicsSpecificity, propagation and memory of pericentric heterochromatin in mouse fibroblasts
We assembled a quantitative map for the abundance and interactions of 16 factors related to PCH in living cells and found that stably bound complexes of the histone methyltransferase Suv39h1/2 demarcate the PCH state. From the experimental data we developed a predictive mathematical model that expla...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-58555 | biostudies-arrayexpress
GenomicsSUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [HiC]
SUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [HiC]
PRJNA1201207 | ENA
GenomicsSUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [RNA-Seq]
SUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [RNA-Seq]
PRJNA1201209 | ENA
GenomicsSUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [ChIP-Seq]
SUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [ChIP-Seq]
PRJNA1201210 | ENA
GenomicsSUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia (ATAC-Seq)
SUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia (ATAC-Seq)
PRJNA1232634 | ENA
OtherSUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [HiC]
Histone 3 Lysine 9 tri-methylation (H3K9me3) is a heterochromatin-associated histone mark deposited broadly across the genome and its regulation is required in normal hematopoiesis. Furthermore, H3K9me3 has been linked with 3D genome organization. However, in the context of acute myeloid leukemia (A...
ORGANISM(S): Homo sapiens 
2026-06-17 | GSE285123 | GEO
TranscriptomicsSUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [RNA-Seq]
Histone 3 Lysine 9 tri-methylation (H3K9me3) is a heterochromatin-associated histone mark deposited broadly across the genome and its regulation is required in normal hematopoiesis. Furthermore, H3K9me3 has been linked with 3D genome organization. However, in the context of acute myeloid leukemia (A...
ORGANISM(S): Homo sapiens 
2026-06-17 | GSE285125 | GEO
GenomicsSUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia (ATAC-Seq)
Histone 3 Lysine 9 tri-methylation (H3K9me3) is a heterochromatin-associated histone mark deposited broadly across the genome and its regulation is required in normal hematopoiesis. Furthermore, H3K9me3 has been linked with 3D genome organization. However, in the context of acute myeloid leukemia (A...
ORGANISM(S): Homo sapiens 
2026-06-17 | GSE291238 | GEO
GenomicsSUV39H1/2-mediated H3K9me3 restricts TE-induced immune response in Acute Myeloid Leukemia [ChIP-Seq]
Histone 3 Lysine 9 tri-methylation (H3K9me3) is a heterochromatin-associated histone mark deposited broadly across the genome and its regulation is required in normal hematopoiesis. Furthermore, H3K9me3 has been linked with 3D genome organization. However, in the context of acute myeloid leukemia (A...
ORGANISM(S): Homo sapiens 
2026-06-17 | GSE285122 | GEO
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