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TranscriptomicsmicroRNA profiles of immune cells and their exosomes
Microarray analysis of exosomal miRNAs vs the miRNAs of their respective donor cells. To determine the miRNA repertoires of exosomes secreted by immune cells, we isolated exosomes from cell supernatants of the Raji B cell line, the Jurkat-derived J77 T cell line, and primary dendritic cells (DCs) de...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-27997 | biostudies-arrayexpress
ProteomicsPeritoneal Cell-Derived Exosomes: Novel Mediators of T Cell Activation and Vaccine Potency in Fish
Exosomes are small extracellular vesicles that play significant roles in cell communication and immune modulation. When considering adaptive immunity, exosomes have been proposed to be involved in T and B cell development, antigen presentation, as well as the cross-presentation of antigens. While th...
ORGANISM(S): Paralichthys olivaceus 
2026-04-06 | PXD059066 | Pride
Vaccine potency Antibody response T-cell activation  fish Exosomes 
TranscriptomicsExosomes mediate protective messages during oxidative stress; role of exosomal shuttle RNA
Exosomes are small extracellular nano-vesicles of endocytic origin that mediate different signals between cells, by surface interactions and by shuttling of functional RNA from one cell to another. In this study, we show that exosomes, produced by mouse mast cells exposed to oxidative stress, change...
ORGANISM(S): Mus musculus 
2011-01-07 | E-GEOD-24886 | biostudies-arrayexpress
TranscriptomicsmiRNAs in Treg-derived Exosomes
Foxp3+ regulatory T (Treg) cells prevent inflammatory disease but the mechanistic basis of suppression is not understood completely . Gene silencing by RNA interference can act in a cell-autonomous and non-cell-autonomous manner, providing mechanisms of inter-cellular regulation. Here, we demonstrat...
ORGANISM(S): Mus musculus 
2014-08-27 | E-GEOD-60615 | biostudies-arrayexpress
ProteomicsImmunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata
We have demonstrated therapeutic efficacy of MDSC in mouse Alopecia Areata (AA). In the same AA model, we now asked whether MDSC exosomes (MDSC-Exo) can replace MDSC. MDSC-Exo from bone marrow cells (BMC) cultures of healthy donors could substantially facilitate treatment. With knowledge on MDSC-Exo...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-08-16 | MSV000082825 | MassIVE
TranscriptomicsmRNA profiles of activated and resting T cells and their exosomes
Microarray analysis of exosomal and cellular mRNAs in activated and resting primary human T lymphoblasts Primary human T lymphoblasts were obtained from eight donors and total RNA was isolated from cells and derived exosomes before and after activation with PMA plus ionomycin.
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-50971 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiles of activated and resting T cells and their exosomes
Microarray analysis of exosomal and cellular miRNAs in activated and resting primary human T lymphoblasts Primary human T lymphoblasts were obtained from eight donors and total RNA was isolated from cells and derived exosomes before and after activation with PMA plus ionomycin.
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-50953 | biostudies-arrayexpress
ProteomicsProteomic analysis of neuroblastoma-derived exosomes LC-MS
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor. At diagnosis, around 70% of patients with metastatic disease present bone-marrow (BM) infiltration; however, the mechanism underlying this specific tropism has to be elucidated. Tumor-derived exosomes may support metastatic pr...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD005864 | Pride
Neuroblastoma Signature Exosomes Proteomics Metastasis 
GenomicsMultimodal Transcriptomic Profiling of T Cell Responses to Triple-Negative Breast Cancer-Derived Exosomes
Multimodal Transcriptomic Profiling of T Cell Responses to Triple-Negative Breast Cancer-Derived Exosomes
PRJNA1290339 | ENA
ProteomicsProteomic Profiling and Functional Analysis of B Cell-Derived Exosomes upon Pneumocystis Infection
Pneumocystis is a life-threatening fungal pathogen frequently causing fatal pneumonia (PCP) in immunocompromised individuals with high mortality. Recently, B cells have been reported to play a crucial role in the pathogenesis of PCP through producing antibodies and activating CD4+ T cell response. E...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-26 | PXD030103 | Pride
Exosomes Mass spectrometry B lymphocytes Pneumocystis pneumonia 
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