Sort   by:  
 Page size 
MetabolomicsGut-derived metabolites drive Th17 cell pathogenicity in multiple sclerosis

The gut-brain axis is an emerging factor in promoting multiple sclerosis (MS). However, the underlying mechanisms and strategies to target this axis are not established. Here, we investigated how the gut environment influences myelin-specific Th17 cell pathogenicity. We used the adoptive Th17 cel...

2025-08-15 | MTBLS980 | MetaboLights
MetabolomicsLipidomic analysis of CD4+ T-cell subsets (Th1,Th2,Th17 and iTreg cells) (part I)
Not available
ORGANISM(S): Homo sapiens 
ST001676 | MetabolomicsWorkbench
MetabolomicsFisetin ameliorates acute colitis in mice via gut microbiota associated linoleic acid metabolism to regulate Th17/Treg balance

This study investigated the therapeutic effects of FST on colitis in mice by exploring its impact on the gut microbiota, metabolites, and immune response. The results show FST alleviated colitis in mice, including mitigated weight loss, improved colon length shortening, and reduced mRNA expressi...

2025-12-03 | MTBLS13284 | MetaboLights
MetabolomicsQuantitative measurements of ceramides and glycosphingolipids in Th17 and iTreg cells (part-II)
Not available
ORGANISM(S): Homo sapiens 
ST001675 | MetabolomicsWorkbench
MetabolomicsQuantitative measurements of sphingomyelins in Th17 cells before and after the knockdown of UGCG gene (GCS pathway: sphingolipid metabolism) (part-V)
Not available
ORGANISM(S): Homo sapiens 
ST001679 | MetabolomicsWorkbench
MetabolomicsQuantitative measurements of sphingolipids in Th17 cells before and after the knockdown of UGCG gene (GCS pathway: sphingolipid metabolism) (part-IV)
Not available
ORGANISM(S): Homo sapiens 
ST001678 | MetabolomicsWorkbench
MetabolomicsQuantitative targeted measurements of sphingolipids in Th17 cells before and after the triple knockdown of SPTLC1,2,3 genes (SPT, de novo pathway: sphingolipid metabolism) (part-III)
Not available
ORGANISM(S): Homo sapiens 
ST001677 | MetabolomicsWorkbench
TranscriptomicsPopulation transcriptional profiling of KO or WT cells,, differentiated in vitro for 48-96h towards Th17 cells
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75104 | biostudies-arrayexpress
TranscriptomicsPopulation transcriptional profiling of in vitro polarized Th17 cells, either sorted for IL17A/GFP+ or unsorted
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75103 | biostudies-arrayexpress
TranscriptomicsChemical Inhibition of the RORγt-dependent Transcriptional Network in Th17 cells [RNA-Seq 2]
RORγt is a transcription factor required for T helper 17 (Th17) cell development. We identified three RORγt-specific inhibitors that suppress Th17 cell responses including Th17 cell-mediated autoimmune disease. We systemically characterized RORγt binding data in the presence and absence of drug with...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-56240 | biostudies-arrayexpress
Sort   by:  
 Page size