trichostatin a - OmicsDI

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CHEBI ID

CHEBI:9199 (2)
CHEBI:3844 (2)
CHEBI:2316 (2)
CHEBI:28036 (2)
CHEBI:88728 (2)
CHEBI:6944 (2)
CHEBI:50118 (2)
CHEBI:9150 (2)
CHEBI:4823 (2)
CHEBI:17382 (2)
CHEBI:32173 (2)
CHEBI:80602 (2)
CHEBI:20538 (2)
CHEBI:156127 (2)
CHEBI:140147 (2)
CHEBI:140096 (2)
CHEBI:27958 (2)
CHEBI:6872 (2)
CHEBI:31550 (2)
CHEBI:165264 (2)
CHEBI:87085 (2)
CHEBI:5108 (2)
CHEBI:81188 (2)
CHEBI:4310 (2)
CHEBI:81591 (2)
CHEBI:66140 (2)
CHEBI:71003 (2)
CHEBI:67337 (2)
CHEBI:27650 (2)
CHEBI:72001 (2)

Metabolite Name

Hexacosanoyl carnitine (3)
Trichostatin (3)
2alpha-(3-Hydroxypropyl)-1alpha,25-dihydroxy-19-norvitamin D3 (3)
(+)-cucurbic acid (3)
8E-Heptadecenedioic acid (3)
N-palmitoyl proline (3)
All-trans-7-hydroxyhexadeca-2,4,8,10-tetraenoic acid (3)
N-stearoyl glycine (3)
Linoleamide (3)
Erucamide (3)
7-Sulfocholic acid (3)
1alpha,22-dihydroxy-23,24,25,26,27-pentanorvitamin D3 (2)
Erythromycin E (2)
Tamarixetin 3-O-sulfate (2)
1alpha,25-dihydroxy-11alpha-[(1R)-oxiranyl]vitamin D3 (2)
N-physeteroyl lysine (2)
GlcCer(d14:1(4E)/24:1(15Z)(2OH)) (2)
20-Fluoroeicosanoic acid (2)
N-(3-hydroxy-octadecanoyl)-homoserine lactone (2)
15-(3,4-dimethyl-5-pentylfuran-2-yl)-pentadecanoic acid (2)
(+)-Dysideapalaunic acid (2)
2E,4E,6Z,8Z-Decatetraenedioic acid (2)
6-undecynoic acid (2)
4-hydroxy-2-octenal (2)
6Z,9Z-Nonadecadien-3-one (2)
Macamide (2)
11alpha-Hemiglutaryloxy-1,25-dihydroxyvitamin D3 (2)
1alpha,25-dihydroxy-23-azavitamin D3 (2)
(+-)-Dalbergioidin (2)
27-Nor-cholestane-pentol (2)

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Classification

protozoa (5)
helminths (3)
fungi (2)

Modification

N6 (2)
N6-dimethyl-L-lysine (2)

Study type

Transcription profiling by array (225)
RNA-seq of coding RNA (36)
ChIP-seq (18)
ChIP-chip by array (9)
Methylation profiling by array (5)
RNA-seq of non coding RNA (5)
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MicroRNA profiling by array (3)
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Release Date

2013 (86)
2014 (85)
2012 (83)
2011 (78)
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2004 (7)
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2002 (6)
2001 (3)
2000 (3)
1999 (2)
1998 (2)
1997 (2)

Lab affiliation

Key Lab of Integrated Crop Pest Management of Shandong, College of Plant Health and Medicine, Qingdao Agricultural University, Qingdao, China (8)
Department of Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA (4)
Institute of Microbiology, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China (2)
Mass Spectrometry Facility, Max Perutz Labs Vienna, University of Vienna, Vienna Biocenter, Dr.-Bohr-Gasse 7, 1030 Vienna (2)
Proteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark (2)
State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China (2)
2The Key Laboratory of Integrated Crop Pest Management of Shandong Province, College of Agronomy and Plant Protection, Qingdao Agricultural University, Qingdao 266109, China (1)
Agronomy College, Henan Agricultural University, China (1)
Army medical university, Chongqing, China (1)
Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Laboratory of Food Quality and Safety, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China (1)
Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China (1)
CAS Center for Excellence in Molecular Plant Sciences (1)
CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China (1)
CEITEC Masaryk University (1)
CRUK Beatson Institute (1)
CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. (1)
Center for Cancer Research,Medical University of Vienna,Borschke-Gasse 8a,1090 Vienna (1)
Chair of Proteomics and Bioanalytics Technische Universitaet Muenchen (1)
Chemistry Institute, LADETEC, Proteomics Laboratory, UFRJ, RJ, Brazil. (1)
Chromosome dynamics and genome stability, Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Feodor-Lynen-Strasse 21, 81377 München, Germany (1)
College of Life Science, Capital Normal University. (1)
College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China. (1)
College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China (1)
College of Plant Health and Medicine, Qingdao Agricultural University, Qingdao, China (1)
Departamento de Bioquímica y Biología Molecular B e Inmunología. Facultad de Química. Universidad de Murcia. Campus de Excelencia Mare Nostrum (1)
Department of Biology Wanek School of Natural Sciences High Point University 1 N University Pkwy High Point, NC 27368 USA (1)
Department of Cellular Biology and Immunology, Lab 201, Instituto de Parasitología y Biomedicina López-Neyra (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Spain. (1)
Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada (1)
Department of Endocrinology and Metabolism, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China 510630 (1)
Department of Microbiology, Army Medical University (1)

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Transcription profiling of human Burkitts lymphoma cell lines treated with trichostatin A vs controls

Histone acetylation alters the chromatin state and thus gene expression and cellular activities. In spite of various applications of Histone Deacetylase inhibitors (DACIs) their mechanism or selectivity is not fully understood. We studied the mechanism by which the DACI Trichostatin A upregulates th...

ORGANISM(S): Homo sapiens

2006-08-07 | E-MEXP-403 | biostudies-arrayexpress

Transcription profiling of murine neurosphere cultures carrying a Bcl2 transgene and treated with histone deacetylase inhibitor Trichostatin A and demethylating agent AzaC to study DNA methylation and histone deacetylation in neural stem cells.

Neurosphere cultures were established from individually isolated E 14.5 forebrains of mouse embryos that carry a bcl2 transgene. Single-cell suspensions were prepared, seeded at 1x105 cells/ml and treated for two days with 150 nM Trichostatin A (TSA; histone deacetylase inhibitor), 500 nM 5-Aza-2-de...

ORGANISM(S): Mus musculus

2007-12-19 | E-GEOD-587 | biostudies-arrayexpress

Transcription profiling of three human multiple myeloma cell lines treated with 5-aza-2-deoxycytidine and/or trichostatin A

To identify epigenetically silenced genes in multiple myeloma (MM) cell lines and to determine the effects of 5-aza-2-deoxycytidine and trichostatin A on gene expression. We treated 3 multiple myeloma cell lines (MM1, NCI-H929, U266) with 5-aza-2-deoxycytidine and/or trichostatin A.

ORGANISM(S): Homo sapiens

2008-02-01 | E-MEXP-1269 | biostudies-arrayexpress

Trichostatin A alters cytoskeleton and energy metabolism of pancreatic adenocarcinoma cells: an in depth proteomic study.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal of all human cancers with a high mortality rate. Resistance to conventional treatments and chemotherapeutics is a typical feature of PDAC. To investigate the causes of drug resistance it is essential to deeply investigate the mechanis...

ORGANISM(S): Homo sapiens (Human)

2017-11-08 | PXD007801 | Pride

Quantitative proteomics characterization on the effect and mechanism of trichostatin A on hippocampus of type II diabetic mice

Cognitive dysfunction is the main feature of diabetic encephalopathy (DE). The effect and mechanism of trichostatin A (TSA) on cognitive function of diabetic mice is not elucidated. Our study revealed the key pathways and vital hubgenes of the effect of TSA on hippocampus of type II diabetic mice, i...

ORGANISM(S): Mus musculus (Mouse)

2025-05-06 | PXD036588 | Pride

Proteomics Diabetic encephalopathy Cognitive function Drug screening Trichostatin a

Transcription profiling of mouse Y1 adrenocortical cells treated with trichostatin

Testing the effect of trichostatin on the expression of genes in Y1 adrenocortical cells

ORGANISM(S): Mus musculus

2007-08-08 | E-MEXP-1197 | biostudies-arrayexpress

Transcription profiling of mouse F9 embryonal carcinoma cells exposed to differentiating agents (retinoic acid or trichostatin A) vs controls

F9 cells were exposed to two different differentiating agents (retinoic acid or trichostatin A both dissolved in 100% ethonal) for 24 hrs. Control cells were exposed to ethonal for 24hrs

ORGANISM(S): Mus musculus

2007-09-29 | E-GEOD-1437 | biostudies-arrayexpress

Transcription profiling of mouse embryonic stem cell line CGR8 grown in presence of Leukemia Inhibitory Factor and treated with trichostatin A

This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at the Institute for Molecular Biology and Biotechnology FORTH, Herakl...

ORGANISM(S): Mus musculus

2009-07-10 | E-TABM-670 | biostudies-arrayexpress

Expression analysis of trichostatin A-treated Aspergillus fumigatus Af293

Investigation of whole genome gene expression level changes in trichostatin A (TSA)-treated A. fumigatus Af293 compared to non-treated A. fumigatus Af293. Species: Aspergillus fumigatus; Strain: Af293; Type of array: Eukaryotic Expression (4plex, 2plex for a TSA-treated sample and 2plex for a non-tr...

ORGANISM(S): Aspergillus fumigatus Af293

2010-06-30 | E-GEOD-19682 | biostudies-arrayexpress

Transcription profiling of Arabidopsis treated with Trichostatin A (TSA) to inhibit of histone deacetylase in Arabiodopsis thaliana

Histone acetylation is involved in the regulation of gene expression in plants and eukaryotes. Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from histones, which is associated with the repression of gene expression. To study the role of histone acetylation in ...

ORGANISM(S): Arabidopsis thaliana

2008-06-12 | E-GEOD-3783 | biostudies-arrayexpress

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