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ModelsNguyenLK2011 - Ubiquitination dynamics in Ring1B/Bmi1 system
NguyenLK2011 - Ubiquitination dynamics in Ring1B-Bmi1 system This theoretical model investigates the dynamics of Ring1B/Bmi1 ubiquitination to identify bistable switch-like and oscillatory behaviour in the system. Michaelis-Menten (MM) equations are used to formulate the model. However, the authors ...
2024-09-02 | BIOMD0000000622 | BioModels
TranscriptomicsSHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
Triple Negative Breast cancer accounts for some of the most aggressive types of breast cancer. By interrogating clinical datasets, we found that the activities of p63 and Hypoxia-Inducible-Factors (HIFs), two master regulators of the invasive and metastatic cancer cell phenotype are linked in TNBC ...
ORGANISM(S): Homo sapiens 
2012-07-18 | E-GEOD-33950 | biostudies-arrayexpress
ProteomicsProteomes and Ubiquitylomes Analysis Reveals the Involvement of Ubiquitination in Protein Degradation
Petal senescence is a complex programmed process. It has been previously demonstrated that treatment with ethylene, a plant hormone involved in senescence, can extensively alter transcriptome and proteome profiles in plants. However, little is known regarding the impact of ethylene on post-translati...
ORGANISM(S): Petunia hybrida (Petunia) 
2020-03-20 | PXD005457 | Pride
Ethylene  ubiquitination  senescence  petunia  protein degradation 
ProteomicsProteomes and Ubiquitylomes Analysis Reveals the Involvement of Ubiquitination in Protein Degradation
Petal senescence is a complex programmed process. It has been previously demonstrated that treatment with ethylene, a plant hormone involved in senescence, can extensively alter transcriptome and proteome profiles in plants. However, little is known regarding the impact of ethylene on post-tra...
ORGANISM(S): Petunia hybrida (Petunia) 
2020-03-20 | PXD005470 | Pride
Ethylene  ubiquitination  senescence  petunia  protein degradation lc-msms 
ProteomicsCharacterization of Endoplasmic Reticulum-Associated Degradation in the human fungal pathogen C. albicans
C. albicans is the most prevalent human fungal pathogen. In immunocompromised individuals, C. albicans can cause serious systemic disease and patients infected with drug-resistant isolates have few treatment options. The Ubiquitin-Proteasome System has not been thoroughly characterized in C. albica...
ORGANISM(S): Candida Albicans (ncbitaxon:5476) 
2023-05-03 | MSV000091843 | MassIVE
ProteomicsLenalidomide induces ubiquitination and degradation of casein kinase 1A1 in del(5q) MDS
Not available
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-26 | MSV000079014 | MassIVE
GenomicsInduced ubiquitination drives ER protein degradation through a VCP-dependent pathway
Induced ubiquitination drives ER protein degradation through a VCP-dependent pathway
PRJNA1530958 | ENA
ProteomicsLenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke J, Udeshi ND, Narla A, Grauman P, Hurst SN, McConkey M, Svinkina T, Heckl D, Comer E, Li X, Ciarlo C, Hartman E, Munshi N, Schenone M, Schreiber SL, Carr SA, Ebert BL. Science 2014, 343, 301-305. doi:10.1126/science.1244851. Lenalidomide is a drug with clinical efficacy in multiple myeloma an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-26 | MSV000079017 | MassIVE
ProteomicsARIH2 is a novel Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection
Discovery of novel host-virus interactions leads to a better understanding of mechanisms underlying infection and points to potential therapeutic targets at the interface between virus and host proteins. Recently, global, virus-host interaction networks have been mapped using affinity purification-m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-29 | MSV000084855 | MassIVE
ProteomicsMonitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation
While defective α-synuclein homeostasis is central to the pathogenesis of Parkinson’s, fundamental questions about its intracellular trafficking remain unresolved. We have developed a bimolecular fluorescence complementation assay in living cells to monitor de novo ubiquitination of α-synuclein. We ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-17 | PXD038364 | Pride
Ubiquitination Degradation Parkinson's Homeostasis Α-synuclein 
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