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ProteomicsUFL1 interactome in human breast cancer cells
Immunoprecipitation of UFL1 followed by mass spectrometry analysis to identify UFL1 binding partners in human breast cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD062297 | Pride
Human Ufl1 Breast cancer cells 
ProteomicsTargeting the UFL1-AKT Cascade Suppresses Triple-Negative Breast Cancer Progression
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease with limited therapeutic options. While UFL1-mediated UFMylation has been implicated in various diseases, its role in TNBC remains unexplored. In this study, we demonstrate that AKT1 directly interacts with UFL1 and unde...
ORGANISM(S): Homo sapiens (Human) 
2025-11-12 | PXD062168 | Pride
Ufl1 Triple-negative breast cancer Akt 
GenomicsUfl1 deficiency causes skin pigmentation by u-pregulation of Endothelin-1
Ufl1 deficiency causes skin pigmentation by u-pregulation of Endothelin-1
PRJNA844018 | ENA
GenomicsUFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
PRJNA1023186 | ENA
UnknownStructural study of UFL1-UFC1 interaction uncovers the role of UFL1 N-terminal helix in ufmylation.
Not available
S-EPMC10702826 | biostudies-literature
TranscriptomicsUfl1 deficiency causes skin pigmentation by u-pregulation of Endothelin-1
Ufmylation (UFM1 modification) is a newly identified ubiquitin-like modification system involved in numerous cellular processes. However, the regulatory mechanisms and biological functions of this modification remain mostly unknown. We have recently reported that Ufmylation family genes have frequen...
ORGANISM(S): Mus musculus 
2025-05-31 | GSE205159 | GEO
UnknownUFL1 promotes histone H4 ufmylation and ATM activation.
Not available
S-EPMC6423285 | biostudies-literature
TranscriptomicsUFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
To better understand the impact of Ufl1 expression in T cells on regulating tumor microenvironment dynamics, we performed single-cell RNA sequencing on purified CD45+ immune cells from MC38 xenografts harvested from Ufl1 cKO or WT C57BL/6 mice.
ORGANISM(S): Mus musculus 
2024-01-30 | GSE244447 | GEO
UnknownTargeting the UFL1-AKT cascade suppresses triple-negative breast cancer progression.
Not available
S-EPMC12820175 | biostudies-literature
UnknownUFL1 promotes survival and function of virtual memory CD8 T cells.
Not available
S-EPMC11952874 | biostudies-literature
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