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MetabolomicsHif1α-Dependent Uncoupling Of Glycolysis Suppresses Tumor Cell Proliferation
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. Paradoxically, it remains unknown why lower glycolysis is compromised in human clear cell renal cell carcinomas (ccRCC), in which HIF1α acts a tumor suppressor by inhibiting cell autonomous proliferatio...
2024-03-15 | MTBLS8901 | MetaboLights
MetabolomicsAkkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease
The gut microbiome is a key factor regulating energy-metabolism, glucose tolerance and the immune system. Akkermansia muciniphila has been identified as being beneficial gut bacterium for metabolic diseases, including obesity and type 2 diabetes (T2D); however, the molecular mechanisms involved in h...
2021-01-13 | MTBLS1824 | MetaboLights
TranscriptomicsTaf7l Modulates Brown Adipose Tissue Formation
Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (Ucp1). Previously, we reported that the TATA-binding protein Associated Factor 7L (Taf7l) is an important regulator of white adipose tissue (WAT) differen...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-55797 | biostudies-arrayexpress
TranscriptomicsAmino acid deprivation due to overexpression of UCP1 in skeletal muscle: signalling via FGF-21
Recent studies on mouse and human skeletal muscle (SM) demonstrated the important link between mitochondrial function and the cellular metabolic adaptation. To identify key compensatory molecular mechanisms in response to chronic mitochondrial distress, we analyzed mice with ectopic SM respiratory u...
ORGANISM(S): Mus musculus 
2015-02-17 | E-GEOD-45991 | biostudies-arrayexpress
TranscriptomicsEffect of forced uncoupling protein-1 expression on 3T3-L1 adipocyte gene expression
The aim of this study was to investigate the molecular basis underlying the response of 3T3-L1 adipocytes to forced expression of UCP1. Keywords: adipocyte, Uncoupling protein 1, microarray
ORGANISM(S): Mus musculus 
2008-03-24 | GSE6643 | GEO
GenomicsPreadipocyte uncoupling protein 1 expression invoked by fibroblast growth factors imprints on post-differentiation white and brown adipocyte function [1]
Preadipocyte uncoupling protein 1 expression invoked by fibroblast growth factors imprints on post-differentiation white and brown adipocyte function [1]
PRJNA1310590 | ENA
UnknownDegradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity.
Not available
S-EPMC5985227 | biostudies-literature
GenomicsMus musculus
Effect of forced uncoupling protein-1 expression on 3T3-L1 adipocyte gene expression
PRJNA98837 | ENA
GenomicsPreadipocyte uncoupling protein 1 expression invoked by fibroblast growth factors imprints on post-differentiation white and brown adipocyte function
Preadipocyte uncoupling protein 1 expression invoked by fibroblast growth factors imprints on post-differentiation white and brown adipocyte function
PRJNA1309609 | ENA
TranscriptomicsImmortalized clonal brown, beige and white adipose cell lines
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-39562 | biostudies-arrayexpress
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