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MetabolomicsIntegrated Multi-omics Elucidation of the Uric Acid Degradation Pathway in Limosilactobacillus fermentum M5e

Hyperuricemia is a growing global health concern associated with gout, renal diseases, and cardiovascular disorders. Current pharmacotherapies are often limited by side effects, underscoring the need for alternative strategies. In this study, we isolated Limosilactobacillus fermentum M5...

2026-01-26 | MTBLS13223 | MetaboLights
MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
TranscriptomicsThe cockroach Blattella germanica obtains nitrogen from uric acid through a metabolic pathway shared with its bacterial endosymbiont
Uric acid stored in the fat body of cockroaches is a nitrogen reservoir mobilized in times of scarcity. The discovery of urease in Blattabacterium cuenoti, the primary endosymbiont of cockroaches, suggests that the endosymbiont may participate in cockroach nitrogen economy. However, bacterial urease...
ORGANISM(S): Blattella germanica 
2014-12-08 | E-GEOD-63921 | biostudies-arrayexpress
MetabolomicsMetabolomic analysis on Microcystis aeruginosa cells under various amino acid supplementation conditions
Threonine, an essential amino acid for translation, exhibits toxicity towards slow-growing cyanobacteria. This prompted us to perform transcriptomic and proteomic analyses using Microcystis aeruginosa cells treated with threonine, revealing a noteworthy upregulation of thrC, annotated as pyridoxal 5...
2025-04-02 | MTBLS11852 | MetaboLights
TranscriptomicsGene expression of abnormal uric acid synthesis animal model of silk worm Bombyx mori.
Uric acid (UA) is the final product of purine metabolism and plays an important role as a physiological antioxidant. In recent years, several different groups have reported a correlation between decreased UA in Parkinson’s disease (PD) and clinical progression and stage of PD. However, little is kno...
ORGANISM(S): Bombyx mori 
2013-07-24 | E-GEOD-37735 | biostudies-arrayexpress
ProteomicsZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion
ZHX3, which encodes for a transcriptional repressor, is associated with fasting blood glucose (FBG) levels and increased type 2 diabetes (T2D) risk but its role in cell types involved in glucose metabolism is not well understood. Here, we show that the deletion of ZHX3 in the human pancreatic β cell...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD046714 | Pride
Beta cell Type 2 diabetes  zhx3  gluconeogenesis  fasting blood glucose  hepatic glucose production  liver  hepatocytes  uric acid  slc17a1 
UnknownActivation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation.
Not available
S-EPMC12805366 | biostudies-literature
GenomicsTranscriptomes of human monocytes after ex vivo exposure to uric acid
Transcriptomes of human monocytes after ex vivo exposure to uric acid
PRJNA421491 | ENA
GenomicsUric acid-inducible genes in bacteria from the human gut microbiome
Uric acid-inducible genes in bacteria from the human gut microbiome
PRJNA850627 | ENA
GenomicsRNAseq of neutrophils treated with Fungi along with or without uric acid or lactic acid
RNAseq of neutrophils treated with Fungi along with or without uric acid or lactic acid
PRJNA924802 | ENA
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