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TranscriptomicsRegulation of human skin pigmentation in situ by repetitive UV exposure - Molecular characterization of responses to UVA, UVB and SSR
To test the hypothesis that different mechanisms and/or factors might be involved in physiological pigmentary responses of the skin to different types of UV, we used whole human genome microarrays and immunohistochemical analyses to characterize human skin in situ to examine how melanocyte-specific ...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-21429 | biostudies-arrayexpress
TranscriptomicsThe alternative complement pathway appears to be a UVA sensor that leads to systemic immunosuppression
Ultraviolet (UV) wavebands in sunlight are immunomodulatory. About half the amount of UVA within a minimum erythemal dose of sunlight is systemically immunosuppressive, while higher doses protect from UVB immunosuppression in mice. We have previously shown that these responses to UVA are genetically...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-15618 | biostudies-arrayexpress
ProteomicsSynergistic effects between rutin and ascorbic acid in the protection of the proteome of 3D-cultured human skin fibroblasts from UVA radiation
This study demonstrates the cooperation of rutin and ascorbic acid in cytoprotective action against UVA induced changes in the context of proteins involved in gene expression, catalytic processes, antioxidant pathways, as well as signalling molecules including transmembrane channels. The main advant...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD018730 | Pride
Skin fibroblasts  uva radiation  rutin  ascorbic acid  proteomics  3d cell culture 
TranscriptomicsUV Photoprotection and Long-lasting Pigmentation from UVA and/or UVB
To test whether there is a photoprotective benefit after different types of suberythemal repetitive UV, a 1.5 MED challenge dose was applied 1 week after the initial 2 weeks of repetitive irradiation.  To determine what different mechanisms and/or factors might be involved in physiological pigmentar...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-56754 | biostudies-arrayexpress
ProteomicsMelanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects
The presence of melanopsin (OPN4) has been shown in cultured murine melanocytes and was associated with ultraviolet A radiation (UVA) reception. We demonstrated the protective role of OPN4 in skin physiology and the increased UVA-induced damage in its absence using proteomics analysis.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-03-29 | MSV000091592 | MassIVE
ProteomicsCBG and EAA for melanocytes protection
Aims: This study aims to assess the effect of simultaneous use of cannabigerol (CBG) and 3-O-ethyl ascorbic acid (EAA) on changes in the skin melanocyte proteome induced by UVA radiation, with particular emphasis on modifications in the structure of metabolically important proteins. Results: Proteom...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD074276 | Pride
Melanocytes  uva radiation  cannabigerol  3-o-ethyl ascorbic acid  proteomics  skin protection 
TranscriptomicsTranscription profiling of UV- or oxidized lipid treated dermal skin fibroblasts
Long wavelength Ultraviolet (UVA-1) radiation causes oxidative stress that leads to the formation of noxious substances within the skin. As a defensive mechanism skin cells produce detoxifying enzymes and antioxidants when they detect modified molecules. We have recently shown that UVA-1 irradiation...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-GEOD-13606 | biostudies-arrayexpress
ProteomicsComparison of the regenerative effect of microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis lipid extracts on redox-dependent metabolic changes in human skin fibroblasts caused by UVA radiation. Proteomic study. (This research is funded by the National Science Center in Poland (Narodowe Centrum Nauki, NCN) within MINIATURA 8 registration no 2024/08/X/NZ7/00029)
Lipid extracts, specifically from marine microalgae Nannochloropsis oceanica (N.o.) and freshwater microalgae Chlorococcum amblystomatis (C.a.) in this research proposal, offer a great potential in the development of new pharmacotherapeutic applications against skin disease, accompanied by oxidative...
ORGANISM(S): Homo sapiens (Human) 
2026-05-06 | PXD078022 | Pride
Microalgae lipid extracts  oxidative stress: inflammation  human skin fibroblasts  proteomics  uva radiation  3d-cell cultures. 
TranscriptomicsRNA-seq of Pseudomonas Aeruginosa grown under sublethal doses of UVA or in the dark up to early logarithmic phase
Ultraviolet A (UVA) radiation is the major fraction of UV radiation reaching the Earth’s surface; its harmful effects on microorganisms obey mainly to oxidative damage, with the consequent loss of bacterial viability. In this work, the global transcriptional response of Pseudomonas aeruginosa expose...
ORGANISM(S): Pseudomonas aeruginosa 
2024-10-22 | E-MTAB-13681 | biostudies-arrayexpress
ProteomicsSpatial proteomics reveals profound subcellular reorganization in human keratinocytes exposed to UVA light
The effects of UV light on the skin have been extensively investigated. However, systematic information about how exposure to UVA light, the least energetic but the most abundant UV radiation reaching the Earth, shapes the subcellular organization of proteins is lacking. Using subcellular fractionat...
ORGANISM(S): Homo sapiens (Human) 
2022-03-06 | PXD027941 | Pride
Spatial proteomics Keratinocytes Uva light 
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