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TranscriptomicsTranscription profiling of human NF1 heterozygous (NF1+/-) melanocytes from a Neurofibromatosis type 1 patient and NF1 wild type (NF1+/+) melanocytes of a healthy control patient
One of the major primary features of the neurocutaneous genetic disorder Neurofibromatosis type 1 are the hyperpigmentary café-au-lait macules where dysregulation of melanocyte development, proliferation and differentiation is considered to play a key etiopathogenic role. To gain better insight in t...
ORGANISM(S): Homo sapiens 
2005-02-05 | E-MEXP-258 | biostudies-arrayexpress
ProteomicsCBG and EAA for melanocytes protection
Aims: This study aims to assess the effect of simultaneous use of cannabigerol (CBG) and 3-O-ethyl ascorbic acid (EAA) on changes in the skin melanocyte proteome induced by UVA radiation, with particular emphasis on modifications in the structure of metabolically important proteins. Results: Proteom...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD074276 | Pride
Melanocytes  uva radiation  cannabigerol  3-o-ethyl ascorbic acid  proteomics  skin protection 
TranscriptomicsExpression profiling of microRNAs in primary melanocytes
DICER is a central regulator of microRNA maturation. However little is known about mechanisms regulating its expression in development or disease. While profiling miRNA expression in differentiating melanocytes, two populations were observed: some upregulated at the pre-miRNA stage, and others upre...
ORGANISM(S): Homo sapiens 
2010-04-15 | E-GEOD-21249 | biostudies-arrayexpress
TranscriptomicsComparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation
We analysed the whole-genome transcriptional profile of 6 cell lines of dark melanocytes (DM) and 6 of light melanocytes (LM) at basal conditions and after UVB at different time points (6, 12 and 24h) to investigate the mechanisms by which melanocytes protect human skin from the damaging effects of ...
ORGANISM(S): Homo sapiens 
2015-08-08 | E-GEOD-70280 | biostudies-arrayexpress
TranscriptomicsExpression profiling reveals novel pathways in the transformation of melanocytes to melanomas. II
Spotted oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma cells...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4576 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of mouse non-tumorigenic melanocytes with and without 5AzaCdR treatment.
Comparison of non-tumorigenic melanocytes responses to 5AzaCdR with control
ORGANISM(S): Mus musculus 
2010-09-01 | E-MEXP-2512 | biostudies-arrayexpress
TranscriptomicsUV irradiation of human melanocytes
Target genes of ultraviolet stress response in cutaneous melanocytes, potentially associated with solar induced melanocarcinogenesis, were characterized by cDNA microarray technology. In cultured normal human melanocytes, 198 genes out of »9000 arrayed were found modulated > 1.9 times following arti...
ORGANISM(S): Homo sapiens 
2007-09-15 | E-GEOD-9016 | biostudies-arrayexpress
GenomicsExosomal miRNA sequencing of UVB-irradiated melanocytes and non-irradiated melanocytes
Exosomal miRNA sequencing of UVB-irradiated melanocytes and non-irradiated melanocytes
PRJNA638807 | ENA
TranscriptomicsTranscription profiling of normal human melanocytes and melanoma cell lines from advanced lesions
Affymetrix oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma ce...
ORGANISM(S): Homo sapiens 
2007-06-22 | E-GEOD-4570 | biostudies-arrayexpress
ProteomicsProteome characterization of XPC-deficient melanocytes generated by CRISPR-Cas9 technology reveals alteration in the expression of several hundred of proteins
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder owing to the defects in one of the factors implicated in nucleotide excision repair (NER) system. The effect of NER deficiency on melanocyte biology has not received much attention up to now from a mechanistic standpoint, due to the l...
ORGANISM(S): Homo sapiens (Human) 
2024-12-17 | PXD042713 | Pride
Immune system Xeroderma pigmentosum Melanocyte Proteomic 
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