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TranscriptomicsSerotonergic regulation of melanocyte conversion: a bioelectric network explains stochastic all-or-none hyperpigmentation
Depolarization of resting membrane potential in select cells in Xenopus larvae induces striking hyperpigmentation due to dysregulation of melanocytes. Here, we show that this non-cell-autonomous process is mediated by cAMP, CREB, and the transcription factors Sox10 and Slug. Our microarray analysis ...
ORGANISM(S): Xenopus laevis 
2015-11-03 | E-GEOD-70834 | biostudies-arrayexpress
TranscriptomicsNRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells
Neuregulin (NRG) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here, we show that NRG1/ERBB3 signaling inhibits melanocyte (MC) maturation and promotes undifferentiated, migratory ...
ORGANISM(S): Mus musculus 
2010-05-07 | E-GEOD-21463 | biostudies-arrayexpress
TranscriptomicsExpression data from normal melanocyte, melanoma cells and their exosomes
This SuperSeries is composed of the following subset Series: GSE35387: Expression data from normal melanocyte, melanoma cells and their exosomes (microRNA) GSE35388: Expression data from normal melanocyte, melanoma cells and their exosomes (mRNA) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-10-10 | E-GEOD-35389 | biostudies-arrayexpress
TranscriptomicsOncogenic BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration [HT-seq]
Most cancer genomics papers to date have focused on aberrations in genomic DNA and protein-coding transcripts. However, around 50% of transcripts have no coding potential and may exist as non-coding RNA. We performed RNA-seq in BRAFv600e melanoma skin cancer and on melanocytes over-expressing oncoge...
ORGANISM(S): Homo sapiens 
2012-04-28 | E-GEOD-33092 | biostudies-arrayexpress
TranscriptomicsAssay for Transposase-Accessible Chromatin sequencing (ATAC-seq) of primary melanocytes from five human donors
ATAC-seq was conducted to map open chromatin regions in five individual primary human melanocyte cultures. The ATAC libraries were sequenced using paired-end sequencing on an Illumina NovaSeq platform. In total, we sequenced 15 ATAC libraries from these five independent primary melanocyte cultures (...
ORGANISM(S): Homo sapiens 
2025-04-24 | E-MTAB-15048 | biostudies-arrayexpress
TranscriptomicsExpression profiling of microRNAs in primary melanocytes
DICER is a central regulator of microRNA maturation. However little is known about mechanisms regulating its expression in development or disease. While profiling miRNA expression in differentiating melanocytes, two populations were observed: some upregulated at the pre-miRNA stage, and others upre...
ORGANISM(S): Homo sapiens 
2010-04-15 | E-GEOD-21249 | biostudies-arrayexpress
GenomicsDissection of melanocyte stem cell transcriptomes during melanocyte regeneration in adult zebrafish
Dissection of melanocyte stem cell transcriptomes during melanocyte regeneration in adult zebrafish
PRJNA785890 | ENA
GenomicsMITF ChIP-seq in primary melanocyte and melanoma as a function of oncogenic BRAF
Thousands of enhancers are characterized in the human genome, yet few have been shown important in cancer. Inhibiting oncokinases, such as EGFR, ALK, HER2, and BRAF, is a mainstay of current cancer therapy but is hindered by innate drug resistance mediated by upregulation of the HGF receptor, MET. T...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-50681 | biostudies-arrayexpress
ProteomicsProteomic profiling of the proteolytic events in the secretome of the transformed phenotype of melanocyte-derived cells using Terminal Amine Isotopic Labeling of Substrates
The comprehensive profiling of the repertoire of secreted proteins from cancer cells and/or tissue samples provides information on the signaling events that take place during oncogenesis as well as on the cross-talk between normal and tumoral cells. Moreover, the analysis of post translational modif...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD010169 | Pride
Cancer Proteomics Keywords: secretome Tails Melanoma N-terminomics 
GenomicNCI Primary Human Melanocyte QTL Study

In order to create a melanocyte-specific eQTL resource, we obtained primary human melanocyte cultures isolated from foreskin of 106 healthy newborn males predominantly of European descent. Melanocytes were cultured in lot-matched culture medium in randomized batches to minimize variability that c...

phs001500 | dbGaP
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