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MetabolomicsUntargeted liver metabolomic profiling of hepatocyte-specific Serpine2-knockout mice following ischemia-reperfusion injury
Untargeted metabolomics was performed to investigate hepatic metabolic changes associated with hepatocyte-specific Serpine2 deletion after ischemia-reperfusion injury. Eight liver samples were collected from Serpine2-floxed control mice (NC) and hepatocyte-specific Serpine2-knockout mice (HKO), with...
2026-10-11 | MTBLS15998 | MetaboLights
TranscriptomicsMiRNA expression profile in human CD34+/CD105- cells derived from the renal artery subsequent to long warm ischemia compared short warm ischemia
MiRNA regulate the maintenance, differentiation and function of stem cells and progenitor cells. miRNA expression of progenitor cells located in the adventital layer of arterial vessels has not been characterized in either animal or human models. Further it is unknown if local arterial miRNA expres...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-68366 | biostudies-arrayexpress
TranscriptomicsGene expression signatures of ischemia on porcine kidney
Using an oligonucleotide microarray we performed differential transcriptomic analysis of porcine kidneys subjected to intense ischemic stress which could be observed in donors deceased after circulatory death situation (60 min warm ischemia then 24h of cold storage in University of Wisconsin solutio...
ORGANISM(S): Sus scrofa 
2016-03-22 | E-GEOD-79418 | biostudies-arrayexpress
TranscriptomicsThe analysis of differential gene expression after remote ischemic preconditioning of renal ischemia reperfusion injury
To investigate the mechanism by which ischemic preconditioning (IPC) produces tissue tolerance to renal ischemia reperfusion injury in a pig model 15 female Yorkshire pigs were divided into three groups: 1: no IPC and 90 minutes warm ischemia; 2: remote IPC with an early window followed by 90 min wa...
ORGANISM(S): Sus scrofa 
2016-09-02 | E-GEOD-72646 | biostudies-arrayexpress
TranscriptomicsExpression data from an ex vivo ischaemia reperfusion model of renal deceased by cardiac death (DCD) donation in rat
In DCD organ donation one of the significant problems for the organ is the inflammatory response due to ischaemia reperfusion injury caused by warm ischaemia prior to retrieval followed by warm reoxygenation upon transplantation. We developed a model where a DCD kidney was retrieved and preserved us...
ORGANISM(S): Rattus norvegicus 
2012-03-22 | E-GEOD-36671 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the RNA cargo of extracellular vesicles released in perfusate and bile during ex situ isolated liver perfusion of porcine livers exposed to 60-minutes warm ischemia vs. control (no warm ischemia)
There is a ever widening gap between the availability of donor livers suitable for transplantation and liver transplant demand of a growing waiting list. To expand the pool of liver grafts, donation after circulatory death is increasingly being used. Livers procured after circulatory death are expos...
ORGANISM(S): Sus scrofa 
2024-09-27 | E-MTAB-11420 | biostudies-arrayexpress
GenomicsCellular Recovery After Prolonged Warm Ischemia of the Whole Body
Cellular Recovery After Prolonged Warm Ischemia of the Whole Body
PRJNA760895 | ENA
TranscriptomicsRenoprotective Effects of Valproic Acid and Dexamethasone in Acute Kidney Ischemia-Reperfusion Injury
Introduction: Renal ischemia-reperfusion (IR) causes acute kidney injury (AKI) with high mortality and morbidity. The objective of this study was to ameliorate kidney IR injury and identify novel biomarkers for kidney injury and repair. Methods: Left renal ischemia was induced in rats by clamping re...
ORGANISM(S): Rattus norvegicus 
2015-07-06 | E-GEOD-58438 | biostudies-arrayexpress
ProteomicsProteomics analysis of different stages during mouse hepatic ischemia-reperfusion injury
6-plex TMT-based quantitative proteomics was used to analysis the proteomic profile in different stages of mouse hepatic ischemia-reperfusion injury.
ORGANISM(S): Mus musculus (Mouse) 
2017-11-23 | PXD007827 | Pride
Mouse 6-plex tmt Liver 
TranscriptomicsTranscription profiling of rat heart transplants from Lewis to Lewis and Lewis to F344 strains with and without cold storage / prolonged cold ischemia.


Annual heart allograft failure in humans rates about 3-5%. The main reason after the first postoperative year is chronic rejection. Myointimal hyperplasia, the hellmark of chronic rejection, results in a specific type of ischemic heart disease. The lack of angina pectoris symptoms allow vent...
ORGANISM(S): Rattus norvegicus 
2010-10-13 | E-MEXP-2301 | biostudies-arrayexpress
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