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MetabolomicsNi-MOFs as a Simple and Effective Nanomedicine for ROS-Mediated Antibacterial Wound Healing via a Themoelectrocatalytic Process

Thermoelectrocatalytic nickel-based metal-organic frameworks (Ni-MOFs) autonomously generate reactive oxygen species (ROS) via human body-ambient temperature differences. They exhibit potent antibacterial activity against wound-infecting pathogens, and effectively promote infected skin wound heal...

2026-03-13 | MTBLS14045 | MetaboLights
MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we analyze MRSA/CRE b...

2026-01-06 | MTBLS13611 | MetaboLights
MetabolomicsMetabolic analysis of wound response in Wolbachia infected Drosophila melanogaster

Viral studies of Drosophila melanogaster typically involve virus injection with a small needle, causing post-injury a wounding/wound healing response, in addition to the effects of viral infection. However, the metabolic response to the needle injury is understudied, and many viral investigations...

2025-11-18 | MTBLS13248 | MetaboLights
MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we ana...

2026-01-06 | MTBLS13603 | MetaboLights
MetabolomicsMetabolic Reprogramming at the A. muelleri–Ar Infection Site

Metabolomic changes were investigated at the infection site of A. muelleri challenged with Ar. Untargeted LC-MS metabolomics was used to profile metabolite variations between control and infected samples, together with QC samples for quality control. Differential metabolites were characterized to...

2026-09-18 | MTBLS15728 | MetaboLights
ProteomicsPeptidomic analysis of bacterial protease activity in acute wound fluids
The clinical assessment of wound infection and related complications is challenging and the development of objective methods to measure wound status and predict healing outcomes is therefore essential. As bacterial protease activities play important roles in infection, analysis of changes in the wou...
ORGANISM(S): Homo sapiens (Human) 
2024-03-07 | PXD037047 | Pride
Human Lc-msms Wound fluids proteases Peptidome 
ProteomicsBioinformatic analysis of the wound peptidome reveals potential biomarkers and antimicrobial peptides
Peptidomic analysis and methodological development of characterization of low molecular weight peptidome of human wound fluids. Wounds are dynamic environments with high proteolytic activity. Therefore, the study of peptides, being the degradational product of proteins, are of interest when diagnosi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD023244 | Pride
Peptidomics wound fluid 
ProteomicsBlinded rerun of infected and uninfected pig wound fluids
This is a blinded rerun of 12 pig wound fluid samples from the study at PXD048892, looking at differences in wound fluid peptidomes based on infecting pathogen.The raw data alongside code for easily loading and processing the data and creating relevant figures is available at https://github.com/Fred...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-05-13 | PXD055074 | Pride
Wound fluid Proteomics Infection Porcine Pig 
TranscriptomicsDermal Wound Transcriptomic Responses to Infection with Pseudomonas aeruginosa versus Klebsiella pneumoniae
Bacterial infections of wounds are associated with poor healing and worse scarring. We sought to identify transcriptomic patterns associated with impaired healing of wounds infected with Klebsiella pneumoniae (K.p.) or Pseudomonas aeruginosa (P.a.) using a rabbit ear wound model. Wounds created on p...
ORGANISM(S): Oryctolagus cuniculus 
2014-01-01 | E-GEOD-51167 | biostudies-arrayexpress
MetabolomicsA gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection
The “gut-lung” axis is crucial for the chronic infection in bronchiectasis. However, the responsible microbe and the mechanism in the “gut-lung” axis of bronchiectasis are still in demand for precise elucidation. Here, we reported that Eggerthella lenta in the gut and taurine ursodeoxycholic acid (T...
2025-02-27 | MTBLS9522 | MetaboLights
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