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GenomicsALKBH5 regulates transcriptomic changes from leptene/zygotene to pachytene/diplotene stages in spermatocytes
ALKBH5 regulates transcriptomic changes from leptene/zygotene to pachytene/diplotene stages in spermatocytes
PRJNA1176537 | ENA
TranscriptomicsSmall RNA and transcriptome profiling of mice deficient in either germline Dgcr8 or Dicer
We used Illumina Small RNA and RNA-Seq kits to prepare both small RNA and RNA-Seq libraries from total RNA isolated from either leptotenze/zygotene or pachytene spermatocytes purified from either Dgcr8 or Dicer germline conditional knockout mice. Conditional knockout mice were generated by using a D...
ORGANISM(S): Mus musculus 
2015-05-06 | E-GEOD-63166 | biostudies-arrayexpress
TranscriptomicsScreening of genes involved in chromosome segregation in meiosis I
Prophase I of male meiosis involves dynamic chromosome segregation processes during early spermatogenesis, including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes r...
ORGANISM(S): Mus musculus 
2010-03-31 | E-GEOD-19532 | biostudies-arrayexpress
ProteomicsWhole cell proteimics of leptotene+zygotene(LZ) and pachytene+diplotene+diakinesis (PDD) of first meiosis prophase of spermatogenesis in male mouse.
2-hydroxyglutarate (2HG) is recognized as an epigenetic regulator in cancer and some transient biological processes. Of all organs, the testis harbors the highest baseline physiological levels of 2HG, yet it’s putative functions in germ cell biology are unknown. Here we show that 2HG is generated in...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-23 | PXD039015 | Pride
Testis Meiosis Spermatogenesis Lc-ms/ms 
TranscriptomicsExpression profiling of isolated populations of prepachytene spermatocytes, pachytene spermatocytes and spermatids of PWD and B6 males
Expression profiling of isolated populations of prepachytene spermatocytes (LP), pachytene spermatocytes (RP) and spermatids (ST) from PWD and B6 was performed to study the genome wide variation in gene expression between two mouse subspecies. To evaluate the transcriptional difference between B6 an...
ORGANISM(S): Mus musculus 
2014-06-01 | GSE49444 | GEO
ProteomicsDynamic of chromosome-binding protein complexes to meiotic prophase I of mouse spermatocyte
Meiotic prophase I (MPI) is the most important event in mammalian meiosis. Even though MPI-related gene expression has been extensively investigated, the status of the chromosome binding proteins (CBPs) and the corresponding complexes in this process has been not scrutinized yet. A quantitative prot...
ORGANISM(S): Mus Musculus 
2023-06-08 | PXD035062 |
TranscriptomicsExpression profiling of isolated populations of prepachytene spermatocytes, pachytene spermatocytes and spermatids of PWD and B6 males
Expression profiling of isolated populations of prepachytene spermatocytes (LP), pachytene spermatocytes (RP) and spermatids (ST) from PWD and B6 was performed to study the genome wide variation in gene expression between two mouse subspecies. To evaluate the transcriptional difference between B6 an...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-49444 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of different spermatogenic cells
To understand the changes in gene expression during spermatogenesis, we did microarray profiling of spermatogonial stem cells, leptotene-zygotene cells and round spermatids. Microarray profiling of pachytene-diplotene cells can be found in E-MTAB-2668.
ORGANISM(S): Mus musculus 
2019-01-14 | E-MTAB-7067 | biostudies-arrayexpress
TranscriptomicsSmall RNA and transcriptome profiling of mice deficient in either germline Dgcr8 or Dicer
We used Illumina Small RNA and RNA-Seq kits to prepare both small RNA and RNA-Seq libraries from total RNA isolated from either leptotenze/zygotene or pachytene spermatocytes purified from either Dgcr8 or Dicer germline conditional knockout mice.
ORGANISM(S): Mus musculus 
2015-05-06 | GSE63166 | GEO
UnknownNuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility.
Not available
S-EPMC8386835 | biostudies-literature
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