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ProteomicsTargeted protein degradation reveals Pol II heterogeneity and functional diversity
RNA polymerase II (Pol II) subunits are thought to be involved in various transcription-associated processes, but it is unclear whether they play different regulatory roles in modulating gene expression. Here, we performed nascent and mature transcript sequencing after the acute degradation of 12 ma...
ORGANISM(S): Mus <genus> 
2022-08-09 | PXD035866 |
TranscriptomicsThe RNA Pol II Elongation Factor Ell3 Marks Enhancers in ES Cells and Primes Future Gene Activation
Enhancers play a central role in precisely regulating the spatiotemporal expression of developmentally regulated genes. The molecular mechanisms and factors required for controlling the inactive or poised enhancers and their function in future gene activation remain elusive. Here, we have identified...
ORGANISM(S): Mus musculus 
2012-12-30 | E-GEOD-38148 | biostudies-arrayexpress
GenomicsGenomic Study of RNA Polymerase II and III SNAPc-Bound Promoters Reveals a Gene Transcribed by both Enzymes and a Broad Use of Common Activators
SNAPc-dependent promoters are unique among cellular promoters in being very similar to each other, even though some of them recruit RNA polymerase II and other RNA polymerase III. We have examined all SNAPc-bound promoters present in the human genome. We find that there is a surprisingly small numbe...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-38303 | biostudies-arrayexpress
ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047572 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047533 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
GenomicsGenomic binding of Pol III transcription machinery and relationship with TFIIS distribution in mouse embryonic stem cells
RNA polymerase (RNA Pol) III synthesizes the tRNAs, the 5S ribosomal RNA and a small number of untranslated RNAs. In vitro, it also transcribes short interspersed nuclear elements (SINEs). We investigated the distribution of RNA Pol III and its associated transcription factors on the genome of mouse...
ORGANISM(S): Mus musculus 
2011-09-16 | E-MTAB-767 | biostudies-arrayexpress
TranscriptomicsEffects of Mediator subunit gene-deletions under conditions that repress ribosome synthesis
Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this response involves the convergence of different nutritional and stress signaling pathways on Maf1, a protein that is essential for repressing tr...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-11397 | biostudies-arrayexpress
GenomicsTargeted protein degradation reveals Pol II heterogeneity and functional diversity [ChIP-Seq]
Targeted protein degradation reveals Pol II heterogeneity and functional diversity [ChIP-Seq]
PRJNA746071 | ENA
GenomicsTargeted protein degradation reveals Pol II heterogeneity and functional diversity [ChAR-Seq]
Targeted protein degradation reveals Pol II heterogeneity and functional diversity [ChAR-Seq]
PRJNA745983 | ENA
GenomicsTargeted protein degradation reveals Pol II heterogeneity and functional diversity [RNA-Seq]
Targeted protein degradation reveals Pol II heterogeneity and functional diversity [RNA-Seq]
PRJNA745445 | ENA
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