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ProteomicsMouse PPAR gamma with/without 15-keto-PGE2
15-keto-PGE2 is proposed as an endogenous ligand of PPAR gamma. The modification of 15-keto-PGE2 can induce PPAR gamma transcriptional activation. This project aims to identify the binding site of 15-keto-PGE2 on PPAR gamma.
ORGANISM(S): Mus musculus (Mouse) 
2025-02-17 | PXD059654 | Pride
15-keto-pge2 Ppar gamma 
Unknown15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARγ-mediated activation of p21WAF1/Cip1.
Not available
S-EPMC3912217 | biostudies-literature
UnknownEnsemble Analysis Identifies Nasal 15-Keto-PGE2 as a Predictor of Recovery in Experimental Rhinovirus Colds.
Not available
S-EPMC8408771 | biostudies-literature
UnknownInhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2.
Not available
S-EPMC4731085 | biostudies-literature
MetabolomicsRabbit plasma metabolomic analysis of Nitroproston: a multi target natural prostaglandin based-drug (Untargeted study)
INTRODUCTION: Nitroproston® is a novel multi-target drug bearing natural prostaglandin E2 (PGE2) and nitric oxide (NO)-donating fragments for treatment of inflammatory and obstructive diseases (i.e. asthma and obstructive bronchitis). OBJECTIVES: To investigate the effects of Nitroproston® adm...
2019-08-27 | MTBLS727 | MetaboLights
TranscriptomicsExpression of HPGD in regulatory T cells prevents adipose tissue inflammation and metabolic dysfunction (data set 2)
Regulatory T cells (Treg cells) are important for the prevention of autoimmunity and lately, their role in maintaining tissue homeostasis has been demonstrated. They exert their function via different suppressive mechanisms including soluble factors. Here, we show that Treg-cell specific expression ...
ORGANISM(S): Mus musculus 
2019-10-07 | GSE123887 | GEO
TranscriptomicsExpression of HPGD in regulatory T cells prevents adipose tissue inflammation and metabolic dysfunction (data set 1)
Regulatory T cells (Treg cells) are important for the prevention of autoimmunity and lately, their role in maintaining tissue homeostasis has been demonstrated. They exert their function via different suppressive mechanisms including soluble factors. Here, we show that Treg-cell specific expression ...
ORGANISM(S): Mus musculus 
2019-10-07 | GSE123886 | GEO
Unknown15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression.
Not available
S-EPMC6859578 | biostudies-literature
UnknownIdentification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity
Not available
S-SCDT-10_1038-S44321-025-00216-4 | biostudies-other
Unknown15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury.
Not available
S-EPMC5397067 | biostudies-literature
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