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UnknownTargeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.
Not available
S-EPMC7597367 | biostudies-literature
ProteomicsMesoscale regulation of microtubule-organising centres by the E3 ligase TRIM37
Centrosomes ensure accurate chromosome segregation during cell division. Although the regulation of centrosome number is well-established, less is known about the suppression of non-centrosomal Microtubule-Organising Centres (ncMTOCs). The E3 ligase TRIM37, implicated in Mulibrey nanism and 17q23-am...
ORGANISM(S): Homo sapiens (Human) 
2025-03-18 | PXD061083 | Pride
E3 ubiquitin ligases Centrosomes and mtocs 17q23-amplified cancers Trim37 Mulibrey nanism disorder Trim proteins Mesoscale protein assembly 
GenomicsTRIM37 is a novel H2A ubiquitin ligase and a Breast Cancer Oncogene
The TRIM37 gene is mutatedin Mulbery nanism, a rare autosomal recessive disorder, and is in the 17q23 chromosomal region that is amplified in up to ~40% of breast cancers. Trim37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases, but the protein substrate(s) of Trim37 is unknown. Mon...
ORGANISM(S): Homo sapiens 
2014-10-06 | GSE48196 | GEO
TranscriptomicsTRIM37 is a novel H2A ubiquitin ligase and a Breast Cancer Oncogene
The TRIM37 gene is mutatedin Mulbery nanism, a rare autosomal recessive disorder, and is in the 17q23 chromosomal region that is amplified in up to ~40% of breast cancers. Trim37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases, but the protein substrate(s) of Trim37 is unknown. Mo...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-48196 | biostudies-arrayexpress
TranscriptomicsTargeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer
Amplification of chromosome 17q23 is a frequent genomic event that occurs in ~ 11% of human breast cancers. The 17q23 amplification is enriched in HER2+ breast cancers, which is significantly correlated with poor clinical outcomes. Previous studies have identified the oncogenic phosphatase WIP1 gene...
ORGANISM(S): Mus musculus 
2018-10-03 | GSE119210 | GEO
UnknownTRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.
Not available
S-EPMC4269325 | biostudies-literature
UnknownProline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer.
Not available
S-EPMC7599336 | biostudies-literature
UnknownComprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer.
Not available
S-EPMC33278 | biostudies-literature
GenomicsHomo sapiens
TRIM37 is a novel H2A ubiquitin ligase and a Breast Cancer Oncogene
PRJNA209139 | ENA
UnknownMesoscale regulation of MTOCs by the E3 ligase TRIM37.
Not available
S-EPMC11482927 | biostudies-literature
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