Sort   by:  
 Page size 
ProteomicsMitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite
L-2-hydroxyglutarate (L-2-HG) is a low-abundance metabolite in mammals, due to the mitochondrial enzyme L-2-HG dehydrogenase (L2HGDH), which oxidizes L-2-HG to 2-oxoglutarate (2-OG) to prevent its accumulation. In humans lacking L2HGDH activity, L-2-HG builds up, leading to L-2-HG aciduria, a rare c...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-31 | PXD054020 | Pride
Mitochondria Metabolism 2-og-dependent dioxygenases Metabolite signaling Gene expression regulation 
Unknown2-oxoglutarate-dependent dioxygenases: A renaissance in attention for ascorbic acid in plants.
Not available
S-EPMC7723244 | biostudies-literature
ProteomicsABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/histone modifications. However, metabolic pathways that regulate these oxygen and 2-OG sensitive enzymes remai...
ORGANISM(S): Homo sapiens (Human) 
2020-07-27 | PXD020128 | Pride
Α-ketoglutarate Lipid peroxidation 2-oxoglutarate dehydrogenase complex Lipoic acid Hypoxia inducible factor 2-oxoglutarate Abhd11 Lipoylation Α-ketoglutarate dehydrogenase complex 
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
UnknownRoles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia.
Not available
S-EPMC7832865 | biostudies-literature
UnknownDistribution and prediction of catalytic domains in 2-oxoglutarate dependent dioxygenases.
Not available
S-EPMC3475032 | biostudies-literature
UnknownABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex.
Not available
S-EPMC7426941 | biostudies-literature
UnknownStructure and Mechanism of a Viral Collagen Prolyl Hydroxylase.
Not available
S-EPMC4613865 | biostudies-literature
UnknownFe(2)OG: an integrated HMM profile-based web server to predict and analyze putative non-haem iron(II)- and 2-oxoglutarate-dependent dioxygenase function in protein sequences.
Not available
S-EPMC7923460 | biostudies-literature
UnknownAspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation.
Not available
S-EPMC5985220 | biostudies-literature
Sort   by:  
 Page size