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MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
ProteomicsABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/histone modifications. However, metabolic pathways that regulate these oxygen and 2-OG sensitive enzymes remai...
ORGANISM(S): Homo sapiens (Human) 
2020-07-27 | PXD020128 | Pride
Α-ketoglutarate Lipid peroxidation 2-oxoglutarate dehydrogenase complex Lipoic acid Hypoxia inducible factor 2-oxoglutarate Abhd11 Lipoylation Α-ketoglutarate dehydrogenase complex 
GenomicsGene expression of Abhd11 knock-out or over-expression embryonic stem cells
Gene expression of Abhd11 knock-out or over-expression embryonic stem cells
PRJNA595847 | ENA
GenomicsABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism
ABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism
PRJNA1240100 | ENA
TranscriptomicsGene expression of Abhd11 knock-out or over-expression embryonic stem cells
Abhd11 is previously identified as a conserved lipase in lipid metabolism. However, its physiological functions in embryonic stem cells (ESCs) are unknown. Based on the construction of ESC lines with conditional Abhd11 expression, we analyst the transcriptome profiling of ESCs upon Abhd11 knock-out ...
ORGANISM(S): Mus musculus 
2020-06-23 | GSE142067 | GEO
TranscriptomicsDifferential expression profiling of Arabidopsis ABHD11 knock-out mutant
ABHD11 has a acylhydrolase activity. Knock-out of abhd11 increases phospholipids in plant leaves. Wholegenome array was done to check the differential expressed genes in lipid metabolic pathway
ORGANISM(S): Arabidopsis thaliana 
2015-10-01 | GSE70672 | GEO
TranscriptomicsABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism
Glutarate is an intermediate of amino acid catabolism and an important metabolite for reprogramming T cell immunity, exerting its effects by inhibition of histone demethylase enzymes or through glutarylation. However, how distinct glutarate modifications are regulated is unclear. Here, we uncover a ...
ORGANISM(S): Homo sapiens 
2025-05-23 | GSE292544 | GEO
GenomicsABHD11-mediated mtDNA transcription restored mitochondrial function to attenuate cardiomyocyte ferroptosis after myocardial infarction
ABHD11-mediated mtDNA transcription restored mitochondrial function to attenuate cardiomyocyte ferroptosis after myocardial infarction
PRJNA1433500 | ENA
UnknownLncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.
Not available
S-EPMC6050509 | biostudies-literature
UnknownMitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function.
Not available
S-EPMC12583646 | biostudies-literature
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