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MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
TranscriptomicsTranscriptional response to 2-oxoglutarate (alpha-ketoglutarate) in Pseduomonas aeruginosa PAO1
The transcriptome of P. aeruginosa PAO1 in the presence of extracelluar 2-oxoglutarate at a concentration of 20 mM. We determined the transcriptional response of P. aeruignosa PAO1 to extracellular 2-oxoglutarate. P. aeruginosa PAO1 was grown in nutrient broth (Oxoid number 2) and induced with 20 m...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2014-02-15 | E-GEOD-54032 | biostudies-arrayexpress
ProteomicsABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/histone modifications. However, metabolic pathways that regulate these oxygen and 2-OG sensitive enzymes remai...
ORGANISM(S): Homo sapiens (Human) 
2020-07-27 | PXD020128 | Pride
Α-ketoglutarate Lipid peroxidation 2-oxoglutarate dehydrogenase complex Lipoic acid Hypoxia inducible factor 2-oxoglutarate Abhd11 Lipoylation Α-ketoglutarate dehydrogenase complex 
TranscriptomicsTranscriptional response to 2-oxoglutarate (alpha-ketoglutarate) in Pseduomonas aeruginosa PAO1
The transcriptome of P. aeruginosa PAO1 in the presence of extracelluar 2-oxoglutarate at a concentration of 20 mM. We determined the transcriptional response of P. aeruignosa PAO1 to extracellular 2-oxoglutarate.
ORGANISM(S): Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 
2014-02-15 | GSE54032 | GEO
ProteomicsMRPS36 provides a missing link in the eukaryotic 2-oxoglutarate dehydrogenase complex for recruitment of E3 to the E2 core - Phospoproteomics data
The tricarboxylic acid (TCA) cycle, or Krebs cycle, is the central pathway of energy production in eukaryotic cells and plays a key part in aerobic respiration throughout all kingdoms of life. The enzymes involved in this cycle generate the reducing equivalents NADH and FADH2 by a series of enzymati...
ORGANISM(S): Bos taurus (Bovine) 
2023-03-10 | PXD036896 | Pride
2-oxoglutarate dehydrogenase (ogdhc)  mrps36  tricarboxylic acid (tca) cycle  krebs cycle  heart mitochondria  cross-linking mass spectrometry  complexome profiling  structural biology  comparative genomics 
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
GenomicsPseudomonas aeruginosa PAO1
Transcriptional response to 2-oxoglutarate (alpha-ketoglutarate) in Pseduomonas aeruginosa PAO1
PRJNA234392 | ENA
UnknownThe Emergence of 2-Oxoglutarate as a Master Regulator Metabolite.
Not available
S-EPMC4651028 | biostudies-literature
UnknownInhibition of JMJD6 by 2-Oxoglutarate Mimics.
Not available
S-EPMC9299220 | biostudies-literature
MetabolomicsMetabolomic Analysis of Fission Yeast at the Onset of Nitrogen Starvation
Microorganisms naturally respond to changes in nutritional conditions by adjusting their morphology and physiology. The cellular response of the fission yeast S. pombe to nitrogen starvation has been extensively studied. Here, we report time course metabolomic analysis during one hour immediately af...
2013-11-26 | MTBLS67 | MetaboLights
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