Sort   by:  
 Page size 
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
ProteomicsABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/histone modifications. However, metabolic pathways that regulate these oxygen and 2-OG sensitive enzymes remai...
ORGANISM(S): Homo sapiens (Human) 
2020-07-27 | PXD020128 | Pride
Α-ketoglutarate Lipid peroxidation 2-oxoglutarate dehydrogenase complex Lipoic acid Hypoxia inducible factor 2-oxoglutarate Abhd11 Lipoylation Α-ketoglutarate dehydrogenase complex 
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
ProteomicsMRPS36 provides a missing link in the eukaryotic 2-oxoglutarate dehydrogenase complex for recruitment of E3 to the E2 core - Phospoproteomics data
The tricarboxylic acid (TCA) cycle, or Krebs cycle, is the central pathway of energy production in eukaryotic cells and plays a key part in aerobic respiration throughout all kingdoms of life. The enzymes involved in this cycle generate the reducing equivalents NADH and FADH2 by a series of enzymati...
ORGANISM(S): Bos taurus (Bovine) 
2023-03-10 | PXD036896 | Pride
2-oxoglutarate dehydrogenase (ogdhc)  mrps36  tricarboxylic acid (tca) cycle  krebs cycle  heart mitochondria  cross-linking mass spectrometry  complexome profiling  structural biology  comparative genomics 
ProteomicsUnusual composition of the mitochondrial pyruvate dehydrogenase complex from the widespread marine protist group diplonemids
In eukaryotes, pyruvate, a key metabolite produced by glycolysis, is converted by a mitochondrial pyruvate dehydrogenase complex (PDH) to acetyl-coenzyme A, which is fed into the tricarboxylic acid cycle. Two additional enzyme complexes catalyze similar oxidative decarboxylation reactions albeit usi...
ORGANISM(S): Diplonema papillatum 
2023-07-28 | PXD035104 | Pride
Paradiplonema papillatum 2-oxoglutarate dehydrogenase Branched-chain ketoacid dehydrogenase 
UnknownABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex.
Not available
S-EPMC7426941 | biostudies-literature
UnknownMolecular architecture of the mammalian 2-oxoglutarate dehydrogenase complex.
Not available
S-EPMC11436768 | biostudies-literature
UnknownMRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex.
Not available
S-EPMC9974300 | biostudies-literature
UnknownCrystal structure of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex.
Not available
S-EPMC7611002 | biostudies-literature
UnknownCellular localization of the hybrid pyruvate/2-oxoglutarate dehydrogenase complex in the actinobacterium Corynebacterium glutamicum.
Not available
S-EPMC10581250 | biostudies-literature
Sort   by:  
 Page size